Zinc in PDB 9o54: ADAM17 Prodomain-Metalloproteinase Domains Bound to MEDI3622 Fab

All present enzymatic activity of ADAM17 Prodomain-Metalloproteinase Domains Bound to MEDI3622 Fab:
3.4.24.86;

The binding sites of Zinc atom in the ADAM17 Prodomain-Metalloproteinase Domains Bound to MEDI3622 Fab (pdb code 9o54). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the ADAM17 Prodomain-Metalloproteinase Domains Bound to MEDI3622 Fab, PDB code: 9o54:

Zinc binding site 1 out of 1 in the ADAM17 Prodomain-Metalloproteinase Domains Bound to MEDI3622 Fab


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of ADAM17 Prodomain-Metalloproteinase Domains Bound to MEDI3622 Fab within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:67.0 occ:1.00 CE1 A:HIS405 2.2 52.5 1.0 NE2 A:HIS415 2.3 56.9 1.0 NE2 A:HIS405 2.3 52.5 1.0 NE2 A:HIS409 2.3 50.1 1.0 CD2 A:HIS409 2.4 50.1 1.0 CE1 A:HIS415 2.5 56.9 1.0 ND1 A:HIS405 3.4 52.5 1.0 CD2 A:HIS415 3.5 56.9 1.0 CD2 A:HIS405 3.5 52.5 1.0 CE1 A:HIS409 3.6 50.1 1.0 ND1 A:HIS415 3.7 56.9 1.0 CG A:HIS409 3.8 50.1 1.0 CG A:HIS405 4.0 52.5 1.0 CG A:HIS415 4.2 56.9 1.0 O A:GLY349 4.2 48.6 1.0 ND1 A:HIS409 4.3 50.1 1.0 CA A:LEU350 4.8 48.6 1.0 CB A:HIS409 4.9 50.1 1.0

J.J.Maciag, C.E.Slone, H.F.Alnajjar, M.F.Rich, B.Guion, I.Ifergan, C.P.Blobel, T.C.M.Seegar. Structural Insights Into the Activation and Inhibition of the ADAM17-IRHOM2 Complex. Proc.Natl.Acad.Sci.Usa V. 122 32122 2025.
ISSN: ESSN 1091-6490
PubMed: 40512800
DOI: 10.1073/PNAS.2500732122