Zinc in PDB 9lvj: Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex

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>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30; Page 4, Binding sites: 31 - 32;

Binding sites:

The binding sites of Zinc atom in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex (pdb code 9lvj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 32 binding sites of Zinc where determined in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex, PDB code: 9lvj:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 32 in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:87.5 occ:1.00 CB A:CYS737 2.1 53.5 1.0 SG A:CYS737 2.3 53.5 1.0 SG A:CYS740 2.3 52.9 1.0 CB A:CYS740 2.4 52.9 1.0 N A:CYS740 3.2 52.9 1.0 CA A:CYS740 3.3 52.9 1.0 CA A:CYS737 3.5 53.5 1.0 N A:GLY741 3.6 50.1 1.0 C A:CYS740 3.9 52.9 1.0 O A:LYS742 4.1 49.8 1.0 N A:CYS737 4.1 53.5 1.0 C A:CYS737 4.2 53.5 1.0 N A:LYS742 4.2 49.8 1.0 SG A:CYS775 4.3 60.2 1.0 C A:PHE739 4.5 51.6 1.0 N A:ASN738 4.5 50.9 1.0 CB A:CYS775 4.6 60.2 1.0 N A:PHE739 4.7 51.6 1.0 CA A:GLY741 4.7 50.1 1.0 O A:CYS737 4.8 53.5 1.0 C A:GLY741 4.9 50.1 1.0 C A:LYS742 4.9 49.8 1.0 O A:CYS740 5.0 52.9 1.0

Zinc binding site 2 out of 32 in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:64.8 occ:1.00 ND1 A:HIS835 2.0 50.0 1.0 ND1 A:HIS838 2.1 48.0 1.0 SG A:CYS788 2.3 49.4 1.0 SG A:CYS785 2.3 51.8 1.0 CG A:HIS835 2.8 50.0 1.0 CE1 A:HIS838 2.9 48.0 1.0 CB A:HIS835 3.0 50.0 1.0 CB A:CYS785 3.0 51.8 1.0 CG A:HIS838 3.2 48.0 1.0 CE1 A:HIS835 3.2 50.0 1.0 N A:HIS835 3.5 50.0 1.0 CB A:CYS788 3.6 49.4 1.0 CB A:HIS838 3.6 48.0 1.0 CA A:HIS835 3.8 50.0 1.0 N A:CYS788 4.0 49.4 1.0 CD2 A:HIS835 4.0 50.0 1.0 NE2 A:HIS838 4.1 48.0 1.0 NE2 A:HIS835 4.2 50.0 1.0 CD2 A:HIS838 4.2 48.0 1.0 CA A:CYS788 4.4 49.4 1.0 CA A:CYS785 4.5 51.8 1.0 C A:GLY834 4.7 44.9 1.0 C A:HIS835 4.7 50.0 1.0 CB A:LEU787 4.8 49.2 1.0 O A:HIS835 4.8 50.0 1.0 CA A:HIS838 4.9 48.0 1.0 CA A:GLY834 4.9 44.9 1.0

Zinc binding site 3 out of 32 in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1003 b:89.8 occ:1.00 SG A:CYS830 2.3 56.6 1.0 SG A:CYS856 2.3 71.5 1.0 SG A:CYS858 2.3 70.3 1.0 SG A:CYS827 2.3 50.5 1.0 CB A:CYS827 3.2 50.5 1.0 CB A:CYS858 3.3 70.3 1.0 CB A:CYS830 3.4 56.6 1.0 CA A:CYS858 3.7 70.3 1.0 N A:CYS830 4.0 56.6 1.0 CB A:CYS856 4.1 71.5 1.0 N A:CYS858 4.2 70.3 1.0 SG A:CYS849 4.3 58.8 1.0 CA A:CYS830 4.3 56.6 1.0 O A:CYS856 4.3 71.5 1.0 CB A:CYS849 4.6 58.8 1.0 C A:CYS856 4.6 71.5 1.0 CA A:CYS827 4.7 50.5 1.0 CB A:ASN829 4.8 52.7 1.0 ZN A:ZN1004 4.8 91.1 1.0 C A:ASN829 4.9 52.7 1.0 CA A:CYS856 4.9 71.5 1.0 C A:LYS857 5.0 70.5 1.0

Zinc binding site 4 out of 32 in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1004 b:91.1 occ:1.00 CD2 A:HIS832 1.8 57.8 1.0 CG A:HIS832 2.0 57.8 1.0 NE2 A:HIS832 2.0 57.8 1.0 SG A:CYS854 2.3 67.4 1.0 SG A:CYS849 2.3 58.8 1.0 ND1 A:HIS832 2.3 57.8 1.0 CE1 A:HIS832 2.4 57.8 1.0 CB A:CYS830 2.9 56.6 1.0 SG A:CYS830 3.0 56.6 1.0 CB A:HIS832 3.0 57.8 1.0 CB A:CYS854 3.6 67.4 1.0 CB A:CYS849 4.0 58.8 1.0 CA A:CYS830 4.2 56.6 1.0 CA A:HIS832 4.3 57.8 1.0 N A:HIS832 4.4 57.8 1.0 C A:CYS830 4.6 56.6 1.0 O A:CYS830 4.7 56.6 1.0 CB A:VAL851 4.7 54.1 1.0 CG2 A:VAL851 4.8 54.1 1.0 ZN A:ZN1003 4.8 89.8 1.0 CA A:CYS854 5.0 67.4 1.0

Zinc binding site 5 out of 32 in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:212.3 occ:1.00 O B:GLY741 2.2 152.3 1.0 CD B:LYS742 3.2 143.4 1.0 C B:GLY741 3.4 152.3 1.0 CG B:LYS742 3.8 143.4 1.0 C B:CYS740 4.0 145.9 1.0 N B:GLY741 4.0 152.3 1.0 O B:CYS740 4.2 145.9 1.0 N B:LYS742 4.3 143.4 1.0 CA B:LYS742 4.3 143.4 1.0 CA B:GLY741 4.3 152.3 1.0 CB B:CYS740 4.3 145.9 1.0 OG B:SER745 4.4 128.9 1.0 CA B:CYS740 4.5 145.9 1.0 CE B:LYS742 4.5 143.4 1.0 CB B:LYS742 4.6 143.4 1.0 NZ B:LYS742 4.8 143.4 1.0 CB B:SER745 4.9 128.9 1.0

Zinc binding site 6 out of 32 in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1002 b:67.1 occ:1.00 CB B:HIS835 2.4 84.1 1.0 CB B:CYS785 2.8 112.5 1.0 N B:HIS835 3.0 84.1 1.0 CA B:HIS835 3.2 84.1 1.0 CB B:CYS788 3.6 101.5 1.0 CA B:CYS785 3.8 112.5 1.0 N B:CYS788 3.8 101.5 1.0 CB B:HIS838 4.1 99.3 1.0 C B:GLY834 4.2 100.2 1.0 CA B:CYS788 4.3 101.5 1.0 C B:CYS785 4.4 112.5 1.0 C B:HIS835 4.5 84.1 1.0 C B:LEU787 4.5 103.1 1.0 CA B:GLY834 4.6 100.2 1.0 N B:LEU787 4.7 103.1 1.0 O B:HIS835 4.8 84.1 1.0 O B:CYS785 4.9 112.5 1.0 N B:ALA786 4.9 118.5 1.0 CB B:LEU787 4.9 103.1 1.0 CA B:LEU787 4.9 103.1 1.0 C B:CYS788 5.0 101.5 1.0 N B:LEU789 5.0 81.6 1.0 N B:CYS785 5.0 112.5 1.0

Zinc binding site 7 out of 32 in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1003 b:139.6 occ:1.00 N B:CYS830 2.1 104.0 1.0 CB B:CYS827 2.4 97.8 1.0 CB B:CYS830 2.6 104.0 1.0 CA B:CYS830 2.8 104.0 1.0 CA B:CYS827 3.2 97.8 1.0 CA B:CYS858 3.2 112.6 1.0 C B:ASN829 3.2 117.5 1.0 N B:ASN829 3.3 117.5 1.0 CB B:CYS858 3.5 112.6 1.0 C B:CYS827 3.5 97.8 1.0 CA B:ASN829 3.6 117.5 1.0 N B:HIS828 3.7 111.8 1.0 C B:CYS830 3.8 104.0 1.0 N B:ARG831 3.9 107.7 1.0 CB B:ASN829 3.9 117.5 1.0 O B:CYS827 4.1 97.8 1.0 O B:CYS858 4.1 112.6 1.0 N B:CYS858 4.1 112.6 1.0 C B:CYS858 4.2 112.6 1.0 C B:HIS828 4.2 111.8 1.0 O B:ASN829 4.3 117.5 1.0 O B:LYS857 4.4 100.5 1.0 O D:ARG932 4.6 108.8 1.0 C B:LYS857 4.6 100.5 1.0 CA B:HIS828 4.6 111.8 1.0 N B:CYS827 4.6 97.8 1.0 O B:CYS856 4.7 95.8 1.0 O B:CYS830 4.8 104.0 1.0 O D:GLY933 4.9 93.8 1.0

Zinc binding site 8 out of 32 in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1004 b:75.1 occ:1.00 CB B:VAL851 2.4 72.7 1.0 CB B:CYS849 2.9 78.0 1.0 CB B:HIS832 3.4 85.7 1.0 N B:VAL851 3.4 72.7 1.0 CA B:VAL851 3.5 72.7 1.0 CB B:CYS830 3.5 104.0 1.0 CA B:CYS849 3.7 78.0 1.0 CB B:CYS854 3.8 85.3 1.0 C B:CYS849 4.0 78.0 1.0 O B:CYS856 4.0 95.8 1.0 O B:CYS830 4.1 104.0 1.0 O B:VAL851 4.4 72.7 1.0 O B:CYS849 4.4 78.0 1.0 C B:VAL851 4.4 72.7 1.0 N B:PRO850 4.4 69.4 1.0 CA B:CYS830 4.6 104.0 1.0 C B:CYS830 4.6 104.0 1.0 C B:PRO850 4.7 69.4 1.0 CA B:HIS832 4.8 85.7 1.0 CB B:CYS858 4.9 112.6 1.0

Zinc binding site 9 out of 32 in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1001 b:72.1 occ:1.00 CB C:CYS736 1.9 61.3 1.0 SG C:CYS722 2.3 58.0 1.0 SG C:CYS719 2.3 56.2 1.0 SG C:CYS733 2.3 56.6 1.0 SG C:CYS736 2.4 61.3 1.0 CB C:CYS722 3.3 58.0 1.0 CA C:CYS736 3.3 61.3 1.0 CB C:CYS733 3.5 56.6 1.0 CB C:CYS719 3.5 56.2 1.0 N C:CYS736 3.6 61.3 1.0 N C:CYS722 3.6 58.0 1.0 ND1 C:HIS721 3.7 57.5 1.0 CA C:CYS722 4.1 58.0 1.0 CB C:HIS721 4.1 57.5 1.0 CG C:HIS721 4.4 57.5 1.0 C C:CYS736 4.4 61.3 1.0 C C:HIS721 4.4 57.5 1.0 CA C:HIS721 4.7 57.5 1.0 CE1 C:HIS721 4.7 57.5 1.0 N C:HIS721 4.7 57.5 1.0 N C:HIS737 4.9 55.9 1.0 C C:ARG735 4.9 59.0 1.0 CA C:CYS719 4.9 56.2 1.0 CA C:CYS733 4.9 56.6 1.0

Zinc binding site 10 out of 32 in the Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Cryo-Em Structure of SESTRIN2 Bound Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1002 b:53.2 occ:1.00 ND1 C:HIS768 2.0 37.3 1.0 ND1 C:HIS765 2.0 37.7 1.0 SG C:CYS746 2.3 33.7 1.0 SG C:CYS743 2.3 37.8 1.0 CE1 C:HIS768 2.5 37.3 1.0 CB C:CYS743 2.5 37.8 1.0 CG C:HIS765 3.0 37.7 1.0 CE1 C:HIS765 3.0 37.7 1.0 CB C:HIS765 3.3 37.7 1.0 CG C:HIS768 3.3 37.3 1.0 CB C:CYS746 3.7 33.7 1.0 NE2 C:HIS768 3.8 37.3 1.0 CA C:CYS743 4.0 37.8 1.0 N C:CYS746 4.1 33.7 1.0 CB C:HIS768 4.1 37.3 1.0 N C:HIS765 4.1 37.7 1.0 NE2 C:HIS765 4.1 37.7 1.0 CD2 C:HIS765 4.1 37.7 1.0 CD2 C:HIS768 4.2 37.3 1.0 CA C:HIS765 4.3 37.7 1.0 CA C:CYS746 4.5 33.7 1.0 C C:CYS743 4.7 37.8 1.0 CG2 C:VAL750 4.7 36.8 1.0 N C:CYS743 4.7 37.8 1.0 CB C:VAL745 4.9 32.6 1.0

M.Y.Su, F.Teng, S.Wang, X.Mai, H.Zeng, J.Li, X.Song, X.Wang, G.Stjepanovic. Cryo-Em Structures of Amino Acid Sensors Bound to the Human GATOR2 Complex. Cell Rep V. 44 16088 2025.
ISSN: ESSN 2211-1247
PubMed: 40742811
DOI: 10.1016/J.CELREP.2025.116088