Zinc in PDB 9knq: Measles Virus L-P Complex in Apo State

All present enzymatic activity of Measles Virus L-P Complex in Apo State:
2.1.1.375; 2.7.7.48; 2.7.7.88;

The binding sites of Zinc atom in the Measles Virus L-P Complex in Apo State (pdb code 9knq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Measles Virus L-P Complex in Apo State, PDB code: 9knq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Measles Virus L-P Complex in Apo State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Measles Virus L-P Complex in Apo State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2201 b:157.9 occ:1.00 NE2 A:HIS1364 2.3 144.5 1.0 CD2 A:HIS1362 2.4 137.7 1.0 SG A:CYS1177 2.4 168.5 1.0 CE1 A:HIS1364 2.6 144.5 1.0 CB A:CYS1177 3.0 168.5 1.0 CG A:HIS1362 3.3 137.7 1.0 NE2 A:HIS1362 3.4 137.7 1.0 CD2 A:HIS1364 3.6 144.5 1.0 CB A:HIS1362 3.8 137.7 1.0 ND1 A:HIS1364 3.9 144.5 1.0 O A:CYS1180 4.4 166.2 1.0 CG A:HIS1364 4.4 144.5 1.0 O A:CYS1177 4.4 168.5 1.0 CA A:CYS1177 4.5 168.5 1.0 CE1 A:HIS1362 4.5 137.7 1.0 ND1 A:HIS1362 4.5 137.7 1.0 CD2 A:TYR1187 4.6 147.5 1.0 CE2 A:TYR1187 4.6 147.5 1.0 CB A:GLU1181 4.8 169.5 1.0 C A:CYS1180 4.8 166.2 1.0 CG A:GLU1181 4.8 169.5 1.0 CG A:TYR1187 4.9 147.5 1.0 C A:CYS1177 4.9 168.5 1.0 CZ A:TYR1187 5.0 147.5 1.0

Zinc binding site 2 out of 2 in the Measles Virus L-P Complex in Apo State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Measles Virus L-P Complex in Apo State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2202 b:217.6 occ:1.00 SG A:CYS1370 2.3 177.8 1.0 SG A:CYS1369 2.6 183.4 1.0 SG A:CYS1132 2.9 139.9 1.0 OE1 A:GLU1164 3.9 131.5 1.0 CB A:CYS1370 4.0 177.8 1.0 CB A:CYS1132 4.0 139.9 1.0 CB A:CYS1369 4.1 183.4 1.0 N A:CYS1370 4.3 177.8 1.0 C A:CYS1369 4.3 183.4 1.0 CA A:CYS1370 4.5 177.8 1.0 O A:CYS1369 4.5 183.4 1.0 CA A:CYS1132 4.6 139.9 1.0 CD A:GLU1164 4.7 131.5 1.0 CA A:CYS1369 4.8 183.4 1.0

Y.Wang, L.Zhao, Y.Zhang, X.Gao, Y.Wang, W.Shi, R.D.Kornberg, H.Zhang. Structures of the Measles Virus Polymerase Complex with Non-Nucleoside Inhibitors and Mechanism of Inhibition. Cell 2025.
ISSN: ISSN 1097-4172
PubMed: 40628260
DOI: 10.1016/J.CELL.2025.06.017