Zinc in PDB 9ip2: Cryo-Em Structure of the Rna-Dependent Rna Polymerase Complex From Marburg Virus

All present enzymatic activity of Cryo-Em Structure of the Rna-Dependent Rna Polymerase Complex From Marburg Virus:
2.1.1.375; 2.7.7.48; 2.7.7.88;

The binding sites of Zinc atom in the Cryo-Em Structure of the Rna-Dependent Rna Polymerase Complex From Marburg Virus (pdb code 9ip2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryo-Em Structure of the Rna-Dependent Rna Polymerase Complex From Marburg Virus, PDB code: 9ip2:

Zinc binding site 1 out of 1 in the Cryo-Em Structure of the Rna-Dependent Rna Polymerase Complex From Marburg Virus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the Rna-Dependent Rna Polymerase Complex From Marburg Virus within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2801 b:74.2 occ:1.00 OE1 A:GLU1140 2.1 61.1 1.0 SG A:CYS1108 2.3 61.9 1.0 SG A:CYS1377 2.3 67.2 1.0 SG A:CYS1376 2.3 83.8 1.0 CD A:GLU1140 3.3 65.4 1.0 CB A:CYS1376 3.6 71.0 1.0 CB A:CYS1108 3.7 61.4 1.0 CB A:CYS1377 3.7 61.2 1.0 N A:CYS1377 3.7 68.6 1.0 CA A:CYS1377 3.8 65.1 1.0 C A:CYS1376 3.9 71.0 1.0 CA A:CYS1108 4.0 61.1 1.0 N A:THR1109 4.1 50.8 1.0 OE2 A:GLU1140 4.2 62.3 1.0 CG A:GLU1140 4.3 61.5 1.0 O A:CYS1376 4.3 74.0 1.0 CA A:CYS1376 4.4 73.0 1.0 C A:CYS1108 4.6 52.5 1.0 CG2 A:THR1109 4.9 55.1 1.0

G.Li, T.Du, J.Wang, K.Jie, Z.Ren, X.Zhang, L.Zhang, S.Wu, H.Ru. Structural Insights Into the Rna-Dependent Rna Polymerase Complexes From Highly Pathogenic Marburg and Ebola Viruses Nat Commun V. 16 3080 2025.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-025-58308-1