Zinc in PDB 8w2t: Cryo-Em Structure of Human Tankyrase 2 Sam-Parp Filament - Apo State (Focused Refinement Map).

All present enzymatic activity of Cryo-Em Structure of Human Tankyrase 2 Sam-Parp Filament - Apo State (Focused Refinement Map).:
2.4.2.30;

The binding sites of Zinc atom in the Cryo-Em Structure of Human Tankyrase 2 Sam-Parp Filament - Apo State (Focused Refinement Map). (pdb code 8w2t). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of Human Tankyrase 2 Sam-Parp Filament - Apo State (Focused Refinement Map)., PDB code: 8w2t:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of Human Tankyrase 2 Sam-Parp Filament - Apo State (Focused Refinement Map).


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Human Tankyrase 2 Sam-Parp Filament - Apo State (Focused Refinement Map). within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1201 b:116.4 occ:1.00 CG D:HIS1084 2.3 78.1 1.0 ND1 D:HIS1084 2.3 78.1 1.0 SG D:CYS1092 2.3 66.9 1.0 SG D:CYS1089 2.3 68.0 1.0 SG D:CYS1081 2.3 73.5 1.0 CE1 D:HIS1084 2.7 78.1 1.0 CD2 D:HIS1084 2.7 78.1 1.0 NE2 D:HIS1084 2.9 78.1 1.0 CB D:HIS1084 3.0 78.1 1.0 N D:HIS1084 3.4 78.1 1.0 CB D:CYS1089 3.4 68.0 1.0 CB D:CYS1092 3.5 66.9 1.0 CB D:CYS1081 3.6 73.5 1.0 CA D:HIS1084 3.8 78.1 1.0 CB D:VAL1083 4.1 77.5 1.0 C D:VAL1083 4.1 77.5 1.0 N D:CYS1092 4.3 66.9 1.0 CA D:CYS1092 4.5 66.9 1.0 CA D:VAL1083 4.5 77.5 1.0 CG1 D:VAL1083 4.6 77.5 1.0 N D:VAL1083 4.7 77.5 1.0 CA D:CYS1089 4.8 68.0 1.0 O D:VAL1083 4.8 77.5 1.0 CB D:ILE1091 4.9 67.9 1.0 C D:HIS1084 4.9 78.1 1.0 CA D:CYS1081 5.0 73.5 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of Human Tankyrase 2 Sam-Parp Filament - Apo State (Focused Refinement Map).


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Human Tankyrase 2 Sam-Parp Filament - Apo State (Focused Refinement Map). within 5.0Å range: probe atom residue distance (Å) B Occ Q:Zn1201 b:114.5 occ:1.00 ND1 Q:HIS1084 2.3 91.3 1.0 SG Q:CYS1089 2.3 77.2 1.0 SG Q:CYS1081 2.3 85.3 1.0 CE1 Q:HIS1084 2.9 91.3 1.0 SG Q:CYS1092 3.0 75.8 1.0 CB Q:CYS1081 3.2 85.3 1.0 CB Q:CYS1089 3.2 77.2 1.0 CB Q:CYS1092 3.3 75.8 1.0 CG Q:HIS1084 3.5 91.3 1.0 N Q:CYS1092 4.0 75.8 1.0 CB Q:HIS1084 4.1 91.3 1.0 NE2 Q:HIS1084 4.1 91.3 1.0 N Q:HIS1084 4.3 91.3 1.0 CA Q:CYS1092 4.3 75.8 1.0 CB Q:VAL1083 4.3 88.7 1.0 CD2 Q:HIS1084 4.4 91.3 1.0 CA Q:CYS1081 4.6 85.3 1.0 CA Q:CYS1089 4.7 77.2 1.0 CA Q:HIS1084 4.8 91.3 1.0 N Q:VAL1083 4.9 88.7 1.0 C Q:VAL1083 4.9 88.7 1.0 CB Q:ILE1091 5.0 80.6 1.0 CA Q:VAL1083 5.0 88.7 1.0

J.Zimmerman, B.F.Malone, E.Finkin-Groner, S.Sun, R.Liang, M.Foronda, E.M.Schatoff, E.Granowsky, S.Goswami, A.Katti, B.Leach, H.Alcorn, T.Tammela, Y.Fukase, T.Khan, D.J.Huggins, J.Ginn, N.Liverton, R.K.Hite, L.E.Dow. A Potent and Selective TNKS2 Inhibitor For Tumor-Selective Wnt Suppression. Biorxiv 2025.
ISSN: ISSN 2692-8205
PubMed: 40093088
DOI: 10.1101/2025.03.04.641305