Atomistry » Zinc » PDB 8ka8-8oko » 8og2
Atomistry »
  Zinc »
    PDB 8ka8-8oko »
      8og2 »

Zinc in PDB 8og2: Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A

Enzymatic activity of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A

All present enzymatic activity of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A, PDB code: 8og2 was solved by A.E.Mechaly, W.Zhang, A.Haouz, M.Green, F.Rodrigues-Lima, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 77.66 / 2.47
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 86.766, 145.69, 155.312, 90, 90, 90
R / Rfree (%) 23.6 / 28.9

Other elements in 8og2:

The structure of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A also contains other interesting chemical elements:

Sodium (Na) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A (pdb code 8og2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A, PDB code: 8og2:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 8og2

Go back to Zinc Binding Sites List in 8og2
Zinc binding site 1 out of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1802

b:50.3
occ:1.00
SG A:CYS1200 2.1 59.1 1.0
ND1 A:HIS1291 2.1 45.3 1.0
SG A:CYS1199 2.2 52.1 1.0
SG A:CYS1294 2.5 48.9 1.0
CB A:CYS1199 2.8 58.0 1.0
CG A:HIS1291 3.0 50.8 1.0
N A:CYS1200 3.1 67.5 1.0
CE1 A:HIS1291 3.1 40.4 1.0
CB A:HIS1291 3.3 61.9 1.0
CB A:CYS1294 3.4 50.6 1.0
CB A:CYS1200 3.4 55.0 1.0
C A:CYS1199 3.6 63.0 1.0
CA A:CYS1199 3.8 61.5 1.0
CA A:CYS1200 3.8 49.8 1.0
CD2 A:HIS1291 4.2 39.7 1.0
NE2 A:HIS1291 4.2 38.5 1.0
N A:HIS1291 4.3 39.3 1.0
CA A:HIS1291 4.4 47.2 1.0
N A:CYS1199 4.5 63.4 1.0
C A:CYS1200 4.5 36.8 1.0
O A:CYS1199 4.6 52.0 1.0
CH2 A:TRP1151 4.6 37.7 1.0
CE2 A:TYR1204 4.7 48.2 1.0
CA A:CYS1294 4.8 45.0 1.0
NH2 A:ARG1682 4.8 23.2 1.0
O A:CYS1200 4.8 37.7 1.0
CZ2 A:TRP1151 5.0 39.6 1.0

Zinc binding site 2 out of 4 in 8og2

Go back to Zinc Binding Sites List in 8og2
Zinc binding site 2 out of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1803

b:70.2
occ:1.00
SG A:CYS1286 2.3 75.6 1.0
SG A:CYS1283 2.4 79.4 1.0
SG A:CYS1308 2.4 74.9 1.0
SG A:CYS1311 2.6 64.3 1.0
CB A:CYS1308 2.6 56.9 1.0
CB A:CYS1286 2.9 57.9 1.0
CB A:CYS1283 3.3 51.1 1.0
CB A:CYS1311 3.4 58.3 1.0
N A:CYS1308 3.5 92.0 1.0
N A:CYS1286 3.5 79.2 1.0
CA A:CYS1308 3.6 74.2 1.0
CA A:CYS1286 3.8 66.7 1.0
C A:CYS1308 4.5 76.4 1.0
N A:CYS1311 4.6 78.1 1.0
CA A:CYS1311 4.6 62.2 1.0
C A:GLU1285 4.7 73.8 1.0
CA A:CYS1283 4.7 59.2 1.0
C A:VAL1307 4.8 81.5 1.0
CG1 A:VAL1307 4.8 61.3 1.0
CG A:ARG1288 4.8 65.9 1.0
CD A:ARG1288 4.9 67.0 1.0

Zinc binding site 3 out of 4 in 8og2

Go back to Zinc Binding Sites List in 8og2
Zinc binding site 3 out of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1804

b:177.0
occ:1.00
SG A:CYS1710 1.9 268.0 1.0
CB A:CYS1729 2.1 240.7 1.0
SG A:CYS1729 2.3 239.6 1.0
CB A:CYS1710 2.4 221.4 1.0
SG A:CYS1707 2.5 144.0 1.0
CA A:CYS1729 3.4 203.3 1.0
N A:CYS1729 3.7 188.3 1.0
ND2 A:ASN1731 3.8 99.4 1.0
CA A:CYS1710 3.8 183.5 1.0
ND1 A:HIS1712 4.0 99.0 1.0
CB A:CYS1707 4.1 127.3 1.0
N A:CYS1710 4.2 178.3 1.0
CB A:HIS1712 4.4 107.6 1.0
CB A:ASN1731 4.5 138.9 1.0
C A:CYS1729 4.5 183.2 1.0
CG A:ASN1731 4.6 123.0 1.0
CG A:HIS1712 4.7 97.4 1.0
CG A:LEU1728 4.7 132.8 1.0
CD2 A:LEU1728 4.8 133.4 1.0
C A:CYS1710 4.8 151.8 1.0
O A:CYS1729 4.9 178.0 1.0
C A:LEU1728 5.0 166.0 1.0

Zinc binding site 4 out of 4 in 8og2

Go back to Zinc Binding Sites List in 8og2
Zinc binding site 4 out of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1805

b:301.2
occ:1.00
ND1 A:HIS1740 2.3 154.2 1.0
CD2 A:HIS1738 2.4 257.8 1.0
CE1 A:TYR1726 2.4 111.4 1.0
CE1 A:HIS1740 2.7 155.2 1.0
CZ A:TYR1726 2.8 119.5 1.0
NE2 A:HIS1738 2.9 271.5 1.0
CD1 A:TYR1726 3.1 109.9 1.0
OH A:TYR1726 3.2 133.6 1.0
SG A:CYS1720 3.6 178.4 1.0
CG A:HIS1740 3.6 156.8 1.0
CG A:HIS1738 3.6 253.0 1.0
CE2 A:TYR1726 3.7 115.5 1.0
SG A:CYS1723 3.9 139.3 1.0
CG A:TYR1726 3.9 115.0 1.0
NE2 A:HIS1740 4.0 155.8 1.0
CD2 A:TYR1726 4.2 109.7 1.0
CE1 A:HIS1738 4.2 276.8 1.0
CB A:HIS1740 4.3 165.6 1.0
CB A:HIS1738 4.4 198.6 1.0
CD2 A:HIS1740 4.4 153.8 1.0
ND1 A:HIS1738 4.5 270.4 1.0
N A:HIS1740 5.0 173.2 1.0

Reference:

A.E.Mechaly, W.Zhang, A.Haouz, M.Green, F.Rodrigues-Lima. Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A To Be Published.
Page generated: Fri Aug 22 11:47:39 2025

Last articles

Mn in 9LJU
Mn in 9LJW
Mn in 9LJS
Mn in 9LJR
Mn in 9LJT
Mn in 9LJV
Mg in 9UA2
Mg in 9R96
Mg in 9VM1
Mg in 9P01
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy