Zinc in PDB 8csz: Iscb and Wrna Bound to Target Dna

The structure of Iscb and Wrna Bound to Target Dna also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Iscb and Wrna Bound to Target Dna (pdb code 8csz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Iscb and Wrna Bound to Target Dna, PDB code: 8csz:

Zinc binding site 1 out of 1 in the Iscb and Wrna Bound to Target Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Iscb and Wrna Bound to Target Dna within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn503 b:124.4 occ:1.00 SG D:CYS265 2.3 89.9 1.0 CE1 D:HIS268 2.3 88.4 1.0 NE2 D:HIS268 2.6 88.4 1.0 ND1 D:HIS268 2.9 88.4 1.0 CD2 D:HIS268 3.4 88.4 1.0 CG D:HIS268 3.5 88.4 1.0 CB D:HIS239 3.6 97.4 1.0 OE2 D:GLU267 3.6 88.6 1.0 CB D:CYS265 3.6 89.9 1.0 CB D:CYS237 3.6 94.8 1.0 SG D:CYS237 3.8 94.8 1.0 CG D:GLU267 4.1 88.6 1.0 CG D:HIS239 4.2 97.4 1.0 CD2 D:HIS239 4.2 97.4 1.0 CD D:GLU267 4.2 88.6 1.0 CB D:HIS268 4.7 88.4 1.0 CA D:HIS239 4.8 97.4 1.0 SG D:CYS234 4.8 91.9 1.0 CB D:CYS234 4.9 91.9 1.0 N D:HIS239 4.9 97.4 1.0 CA D:CYS237 4.9 94.8 1.0 CA D:CYS265 5.0 89.9 1.0

G.Schuler, C.Hu, A.Ke. Structural Basis For Rna-Guided Dna Cleavage By Iscb-Omega Rna and Mechanistic Comparison with CAS9. Science V. 376 1476 2022.
ISSN: ESSN 1095-9203
PubMed: 35617371
DOI: 10.1126/SCIENCE.ABQ7220