Zinc in PDB 7lhf: Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State

The binding sites of Zinc atom in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State (pdb code 7lhf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State, PDB code: 7lhf:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2808 b:48.5 occ:1.00 SG A:CYS2611 2.3 33.1 1.0 NE2 A:HIS2631 2.3 40.2 1.0 ND1 A:HIS2636 2.3 37.2 1.0 CB A:CYS2614 2.5 36.2 1.0 CD2 A:HIS2631 3.0 40.2 1.0 CB A:CYS2611 3.1 33.1 1.0 CG A:HIS2636 3.2 37.2 1.0 CE1 A:HIS2636 3.3 37.2 1.0 CB A:HIS2636 3.4 37.2 1.0 CE1 A:HIS2631 3.4 40.2 1.0 N A:CYS2614 3.5 36.2 1.0 CA A:CYS2614 3.6 36.2 1.0 SG A:CYS2614 3.7 36.2 1.0 CG A:HIS2631 4.3 40.2 1.0 CD2 A:HIS2636 4.4 37.2 1.0 NE2 A:HIS2636 4.4 37.2 1.0 ND1 A:HIS2631 4.4 40.2 1.0 CA A:CYS2611 4.6 33.1 1.0 C A:CYS2614 4.6 36.2 1.0 C A:ILE2613 4.8 29.4 1.0 N A:GLY2615 4.8 40.8 1.0 CA A:HIS2636 4.9 37.2 1.0

Zinc binding site 2 out of 4 in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn5101 b:48.6 occ:1.00 SG D:CYS2611 2.3 32.5 1.0 NE2 D:HIS2631 2.3 40.4 1.0 ND1 D:HIS2636 2.3 37.8 1.0 CB D:CYS2614 2.5 35.8 1.0 CD2 D:HIS2631 3.0 40.4 1.0 CB D:CYS2611 3.1 32.5 1.0 CG D:HIS2636 3.2 37.8 1.0 CE1 D:HIS2636 3.3 37.8 1.0 CB D:HIS2636 3.4 37.8 1.0 CE1 D:HIS2631 3.4 40.4 1.0 N D:CYS2614 3.5 35.8 1.0 CA D:CYS2614 3.6 35.8 1.0 SG D:CYS2614 3.7 35.8 1.0 CG D:HIS2631 4.3 40.4 1.0 CD2 D:HIS2636 4.4 37.8 1.0 NE2 D:HIS2636 4.4 37.8 1.0 ND1 D:HIS2631 4.4 40.4 1.0 CA D:CYS2611 4.6 32.5 1.0 C D:CYS2614 4.6 35.8 1.0 C D:ILE2613 4.8 29.1 1.0 N D:GLY2615 4.8 39.3 1.0 CA D:HIS2636 4.9 37.8 1.0

Zinc binding site 3 out of 4 in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2808 b:47.2 occ:1.00 SG B:CYS2611 2.3 32.4 1.0 NE2 B:HIS2631 2.3 39.9 1.0 ND1 B:HIS2636 2.3 37.5 1.0 CB B:CYS2614 2.5 35.4 1.0 CD2 B:HIS2631 3.0 39.9 1.0 CB B:CYS2611 3.1 32.4 1.0 CG B:HIS2636 3.2 37.5 1.0 CE1 B:HIS2636 3.3 37.5 1.0 CB B:HIS2636 3.4 37.5 1.0 CE1 B:HIS2631 3.4 39.9 1.0 N B:CYS2614 3.5 35.4 1.0 CA B:CYS2614 3.6 35.4 1.0 SG B:CYS2614 3.7 35.4 1.0 CG B:HIS2631 4.3 39.9 1.0 CD2 B:HIS2636 4.4 37.5 1.0 NE2 B:HIS2636 4.4 37.5 1.0 ND1 B:HIS2631 4.4 39.9 1.0 CA B:CYS2611 4.6 32.4 1.0 C B:CYS2614 4.6 35.4 1.0 C B:ILE2613 4.8 28.9 1.0 N B:GLY2615 4.8 39.0 1.0 CA B:HIS2636 4.9 37.5 1.0

Zinc binding site 4 out of 4 in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn5101 b:45.9 occ:1.00 NE2 C:HIS2631 2.3 40.3 1.0 SG C:CYS2611 2.3 32.1 1.0 ND1 C:HIS2636 2.3 37.7 1.0 CB C:CYS2614 2.5 35.2 1.0 CD2 C:HIS2631 3.0 40.3 1.0 CB C:CYS2611 3.1 32.1 1.0 CG C:HIS2636 3.2 37.7 1.0 CE1 C:HIS2636 3.3 37.7 1.0 CB C:HIS2636 3.4 37.7 1.0 CE1 C:HIS2631 3.4 40.3 1.0 N C:CYS2614 3.5 35.2 1.0 CA C:CYS2614 3.6 35.2 1.0 SG C:CYS2614 3.7 35.2 1.0 CG C:HIS2631 4.3 40.3 1.0 CD2 C:HIS2636 4.4 37.7 1.0 NE2 C:HIS2636 4.4 37.7 1.0 ND1 C:HIS2631 4.4 40.3 1.0 CA C:CYS2611 4.6 32.1 1.0 C C:CYS2614 4.6 35.2 1.0 N C:GLY2615 4.8 39.5 1.0 C C:ILE2613 4.8 28.7 1.0 CA C:HIS2636 4.9 37.7 1.0

M.R.Baker, G.Fan, A.B.Seryshev, M.A.Agosto, M.L.Baker, I.I.Serysheva. Cryo-Em Structure of Type 1 IP3R Channel in A Lipid Bilayer Commun Biol V. 4 625 2021.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-021-02156-4