Zinc in PDB 7ktp: PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome

All present enzymatic activity of PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome:
2.1.1.356;

The binding sites of Zinc atom in the PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome (pdb code 7ktp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 7 binding sites of Zinc where determined in the PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome, PDB code: 7ktp:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7;

Zinc binding site 1 out of 7 in the PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn801 b:149.0 occ:1.00 SG A:CYS302 2.5 110.7 1.0 SG A:CYS307 2.6 115.7 0.9 ND1 A:HIS310 2.6 109.7 1.0 CE1 A:HIS310 2.6 109.7 1.0 CD2 A:LEU309 2.6 108.9 1.0 CB A:CYS302 2.8 110.7 1.0 CB A:CYS307 3.1 115.7 1.0 CG A:LEU309 3.7 108.9 1.0 NE2 A:HIS310 3.8 109.7 1.0 CG A:HIS310 3.8 109.7 1.0 SG A:CYS299 4.1 116.4 1.0 CA A:CYS302 4.2 110.7 1.0 NE2 A:GLN119 4.3 111.5 1.0 CD2 A:HIS310 4.4 109.7 1.0 CD1 A:LEU309 4.5 108.9 1.0 N A:CYS302 4.5 110.7 1.0 CA A:CYS307 4.6 115.7 1.0 CB A:HIS310 4.7 109.7 1.0 N A:HIS310 4.8 109.7 1.0 N A:LEU309 4.9 108.9 1.0 CB A:LEU309 4.9 108.9 1.0 N A:PHE308 5.0 113.4 1.0 CB A:CYS299 5.0 116.4 1.0

Zinc binding site 2 out of 7 in the PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn802 b:196.8 occ:1.00 ZN A:ZN803 2.4 220.9 1.0 SG A:CYS531 2.6 169.0 1.0 SG A:CYS550 2.6 148.5 1.0 SG A:CYS544 2.8 139.9 1.0 CB A:CYS544 3.3 139.9 1.0 CB A:CYS550 3.5 148.5 1.0 ZN A:ZN804 3.7 195.4 1.0 SG A:CYS554 3.7 145.4 1.0 CB A:CYS531 4.0 169.0 1.0 CG A:ARG557 4.0 137.8 1.0 CB A:CYS554 4.3 145.4 1.0 CB A:ASN556 4.3 145.0 1.0 ND2 A:ASN556 4.6 145.0 1.0 SG A:CYS548 4.6 137.3 1.0 N A:ARG557 4.7 137.8 1.0 CD A:ARG557 4.7 137.8 1.0 CA A:CYS544 4.8 139.9 1.0 CE1 A:HIS526 4.8 154.4 1.0 CG A:ASN556 4.9 145.0 1.0 CA A:CYS550 5.0 148.5 1.0

Zinc binding site 3 out of 7 in the PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn803 b:220.9 occ:1.00 ZN A:ZN804 2.3 195.4 1.0 ZN A:ZN802 2.4 196.8 1.0 SG A:CYS544 2.6 139.9 1.0 SG A:CYS531 2.6 169.0 1.0 SG A:CYS535 3.4 153.1 1.0 CB A:CYS531 3.5 169.0 1.0 NE2 A:HIS526 3.7 154.4 1.0 CE1 A:HIS526 3.7 154.4 1.0 ND2 A:ASN556 3.9 145.0 1.0 SG A:CYS537 4.1 143.8 0.9 CB A:CYS544 4.1 139.9 1.0 CB A:CYS537 4.3 143.8 1.0 SG A:CYS550 4.4 148.5 1.0 CB A:CYS550 4.4 148.5 1.0 SG A:CYS524 4.4 134.4 1.0 CA A:CYS531 4.4 169.0 1.0 SG A:CYS548 4.5 137.3 1.0 CB A:CYS535 4.5 153.1 1.0 CB A:ASN556 4.8 145.0 1.0 CG A:ASN556 4.8 145.0 1.0

Zinc binding site 4 out of 7 in the PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn804 b:195.4 occ:1.00 ZN A:ZN803 2.3 220.9 1.0 SG A:CYS548 2.6 137.3 1.0 SG A:CYS524 2.6 134.4 1.0 SG A:CYS537 3.1 143.8 0.9 SG A:CYS544 3.3 139.9 1.0 NE2 A:HIS526 3.5 154.4 1.0 SG A:CYS535 3.6 153.1 1.0 ZN A:ZN802 3.7 196.8 1.0 CE1 A:HIS526 3.7 154.4 1.0 CB A:CYS548 3.7 137.3 1.0 CB A:CYS537 4.3 143.8 1.0 CB A:CYS544 4.3 139.9 1.0 CB A:CYS524 4.4 134.4 1.0 CB A:CYS550 4.4 148.5 1.0 SG A:CYS531 4.4 169.0 1.0 SG A:CYS550 4.6 148.5 1.0 CD2 A:HIS526 4.7 154.4 1.0 N A:CYS524 4.8 134.4 1.0 ND1 A:HIS526 4.9 154.4 1.0

Zinc binding site 5 out of 7 in the PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn805 b:259.4 occ:1.00 ZN A:ZN807 2.5 256.1 1.0 SG A:CYS581 2.5 146.5 1.0 SG A:CYS589 2.6 177.7 1.0 SG A:CYS561 2.6 170.4 1.0 CB A:CYS586 2.8 153.3 1.0 CB A:CYS581 3.2 146.5 1.0 SG A:CYS586 3.2 153.3 1.0 CB A:CYS589 3.5 177.7 1.0 ZN A:ZN806 3.5 260.7 1.0 SG A:CYS602 4.0 149.2 1.0 CA A:CYS586 4.2 153.3 1.0 CA A:CYS581 4.2 146.5 1.0 CB A:CYS561 4.3 170.4 1.0 SG A:CYS567 4.4 172.7 1.0 O A:CYS586 4.5 153.3 1.0 C A:CYS586 4.7 153.3 1.0 N A:ASP582 4.8 136.4 1.0 O A:ASP582 4.8 136.4 1.0 CB A:ALA591 4.8 146.5 1.0 CA A:CYS589 4.9 177.7 1.0

Zinc binding site 6 out of 7 in the PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn806 b:260.7 occ:1.00 SG A:CYS561 2.5 170.4 1.0 SG A:CYS567 2.6 172.7 1.0 SG A:CYS572 2.7 183.1 1.0 CB A:CYS561 2.9 170.4 1.0 ZN A:ZN807 3.0 256.1 1.0 SG A:CYS581 3.0 146.5 1.0 CB A:CYS567 3.3 172.7 1.0 ZN A:ZN805 3.5 259.4 1.0 CB A:CYS574 4.2 153.7 1.0 CB A:CYS572 4.2 183.1 1.0 SG A:CYS574 4.3 153.7 1.0 O A:CYS567 4.4 172.7 1.0 CA A:CYS561 4.4 170.4 1.0 CA A:CYS567 4.7 172.7 1.0 CB A:CYS581 4.7 146.5 1.0 SG A:CYS563 4.8 197.4 1.0 N A:CYS561 4.9 170.4 1.0 C A:CYS567 5.0 172.7 1.0

Zinc binding site 7 out of 7 in the PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of PRC2:EZH1_B From A Dimeric PRC2 Bound to A Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn807 b:256.1 occ:1.00 ZN A:ZN805 2.5 259.4 1.0 SG A:CYS567 2.6 172.7 1.0 CB A:CYS589 2.7 177.7 1.0 ZN A:ZN806 3.0 260.7 1.0 SG A:CYS561 3.0 170.4 1.0 SG A:CYS589 3.2 177.7 1.0 CB A:CYS567 3.4 172.7 1.0 SG A:CYS581 3.4 146.5 1.0 SG A:CYS602 3.6 149.2 1.0 CA A:CYS589 4.1 177.7 1.0 O A:CYS563 4.2 197.4 1.0 CB A:CYS602 4.3 149.2 1.0 O A:THR565 4.4 186.5 1.0 CB A:CYS561 4.6 170.4 1.0 O A:GLN566 4.6 159.6 1.0 N A:CYS589 4.7 177.7 1.0 CA A:CYS567 4.7 172.7 1.0 C A:GLN566 4.8 159.6 1.0 CA A:CYS602 4.9 149.2 1.0 CB A:CYS581 4.9 146.5 1.0 N A:CYS567 5.0 172.7 1.0

D.J.Grau, Y.Zhang, C.H.Lee, M.Valenia-Sanchez, J.Zhang, M.Wang, M.Holder, V.Svetlov, T.Dongyan, E.Nudler, D.Reinberg, T.Walz. Structures of Monomeric and Dimeric PRC2:EZH1 Reveal Flexible Modules Involved in Chromatin Compaction To Be Published.