Atomistry » Zinc » PDB 7g5x-7g70 » 7g6g
Atomistry »
  Zinc »
    PDB 7g5x-7g70 »
      7g6g »

Zinc in PDB 7g6g: Crystal Structure of Rat Autotaxin in Complex with 3-[(2-Tert-Butyl-4- Chloro-5-Methylphenoxy)Methyl]-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3- C]Pyridine

Enzymatic activity of Crystal Structure of Rat Autotaxin in Complex with 3-[(2-Tert-Butyl-4- Chloro-5-Methylphenoxy)Methyl]-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3- C]Pyridine

All present enzymatic activity of Crystal Structure of Rat Autotaxin in Complex with 3-[(2-Tert-Butyl-4- Chloro-5-Methylphenoxy)Methyl]-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3- C]Pyridine:
3.1.4.39;

Protein crystallography data

The structure of Crystal Structure of Rat Autotaxin in Complex with 3-[(2-Tert-Butyl-4- Chloro-5-Methylphenoxy)Methyl]-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3- C]Pyridine, PDB code: 7g6g was solved by M.Stihle, J.Benz, D.Hunziker, H.Kuhne, M.G.Rudolph, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.94 / 1.79
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 83.98, 91.888, 119.682, 90, 90, 90
R / Rfree (%) 19 / 23.3

Other elements in 7g6g:

The structure of Crystal Structure of Rat Autotaxin in Complex with 3-[(2-Tert-Butyl-4- Chloro-5-Methylphenoxy)Methyl]-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3- C]Pyridine also contains other interesting chemical elements:

Calcium (Ca) 2 atoms
Sodium (Na) 2 atoms
Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Rat Autotaxin in Complex with 3-[(2-Tert-Butyl-4- Chloro-5-Methylphenoxy)Methyl]-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3- C]Pyridine (pdb code 7g6g). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Rat Autotaxin in Complex with 3-[(2-Tert-Butyl-4- Chloro-5-Methylphenoxy)Methyl]-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3- C]Pyridine, PDB code: 7g6g:

Zinc binding site 1 out of 1 in 7g6g

Go back to Zinc Binding Sites List in 7g6g
Zinc binding site 1 out of 1 in the Crystal Structure of Rat Autotaxin in Complex with 3-[(2-Tert-Butyl-4- Chloro-5-Methylphenoxy)Methyl]-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3- C]Pyridine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Rat Autotaxin in Complex with 3-[(2-Tert-Butyl-4- Chloro-5-Methylphenoxy)Methyl]-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3- C]Pyridine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn906

b:20.9
occ:1.00
 O A:HOH1404 1.8 26.8 1.0
OD1 A:ASP311 2.0 22.1 1.0
NE2 A:HIS474 2.1 17.2 1.0
NE2 A:HIS315 2.1 22.9 1.0
OD2 A:ASP311 2.5 21.8 1.0
CG A:ASP311 2.6 20.1 1.0
CD2 A:HIS315 3.0 20.9 1.0
CD2 A:HIS474 3.0 16.7 1.0
CE1 A:HIS474 3.1 16.8 1.0
CE1 A:HIS315 3.1 22.2 1.0
O A:HOH1007 4.1 30.2 1.0
CB A:ASP311 4.1 18.6 1.0
CG A:HIS315 4.2 21.2 1.0
CE1 A:HIS359 4.2 17.9 1.0
ND1 A:HIS474 4.2 15.7 1.0
CG A:HIS474 4.2 15.6 1.0
ND1 A:HIS315 4.2 21.3 1.0
OG1 A:THR209 4.5 24.7 1.0
O A:HOH1058 4.5 44.8 1.0
NE2 A:HIS359 4.5 16.6 1.0
CE A:MET361 4.5 16.9 1.0
CA A:CA904 4.5 43.6 1.0
OD1 A:ASP171 4.8 26.6 1.0
O A:ASP311 4.8 19.7 1.0
OD2 A:ASP171 4.9 34.4 1.0
CA A:ASP311 5.0 19.0 1.0

Reference:

D.Hunziker, S.C.Joachim, C.Ullmer, M.G.Rudolph. Crystal Structure of A Rat Autotaxin Complex To Be Published.
Page generated: Sun Feb 9 00:33:09 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy