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Zinc in PDB 7elc: Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna

Enzymatic activity of Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna

All present enzymatic activity of Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna:
2.7.7.48;

Other elements in 7elc:

The structure of Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna also contains other interesting chemical elements:

Manganese (Mn) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna (pdb code 7elc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna, PDB code: 7elc:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 7elc

Go back to Zinc Binding Sites List in 7elc
Zinc binding site 1 out of 4 in the Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2302

b:68.6
occ:1.00
ND1 A:HIS472 2.0 47.0 1.0
SG A:CYS284 2.4 39.0 1.0
SG A:CYS287 2.4 38.9 1.0
SG A:CYS470 2.4 67.4 1.0
CE1 A:HIS472 2.5 47.0 1.0
CB A:CYS284 3.1 39.0 1.0
CG A:HIS472 3.1 47.0 1.0
CB A:CYS287 3.4 38.9 1.0
CB A:CYS470 3.6 67.4 1.0
NE2 A:HIS472 3.6 47.0 1.0
CA A:CYS470 3.7 67.4 1.0
CB A:HIS472 3.9 47.0 1.0
N A:CYS287 3.9 38.9 1.0
CD2 A:HIS472 3.9 47.0 1.0
C A:CYS470 4.1 67.4 1.0
O A:CYS470 4.2 67.4 1.0
CA A:CYS287 4.2 38.9 1.0
CA A:CYS284 4.5 39.0 1.0
C A:PHE286 4.9 33.7 1.0
CB A:PHE286 4.9 33.7 1.0
O A:ILE469 4.9 69.3 1.0
N A:ARG471 4.9 58.8 1.0
C A:CYS284 5.0 39.0 1.0
O A:CYS284 5.0 39.0 1.0
N A:HIS472 5.0 47.0 1.0

Zinc binding site 2 out of 4 in 7elc

Go back to Zinc Binding Sites List in 7elc
Zinc binding site 2 out of 4 in the Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2303

b:94.6
occ:1.00
SG A:CYS1650 2.4 76.8 1.0
SG A:CYS1655 2.4 66.7 1.0
SG A:CYS1652 2.4 78.4 1.0
SG A:CYS1664 2.4 59.4 1.0
CB A:CYS1650 2.7 76.8 1.0
CB A:CYS1655 3.0 66.7 1.0
CB A:CYS1664 3.3 59.4 1.0
N A:CYS1655 3.3 66.7 1.0
N A:CYS1652 3.5 78.4 1.0
CB A:CYS1652 3.6 78.4 1.0
CA A:CYS1655 3.7 66.7 1.0
C A:CYS1650 3.8 76.8 1.0
CA A:CYS1650 3.8 76.8 1.0
N A:THR1651 3.9 81.4 1.0
CA A:CYS1652 4.0 78.4 1.0
C A:ILE1654 4.2 65.7 1.0
O A:CYS1650 4.3 76.8 1.0
CA A:CYS1664 4.4 59.4 1.0
N A:ILE1654 4.4 65.7 1.0
N A:CYS1664 4.4 59.4 1.0
CB A:ILE1654 4.5 65.7 1.0
C A:CYS1652 4.5 78.4 1.0
C A:THR1651 4.5 81.4 1.0
CA A:ILE1654 4.6 65.7 1.0
CA A:THR1651 4.6 81.4 1.0
O A:CYS1652 4.8 78.4 1.0
N A:CYS1650 4.9 76.8 1.0
C A:CYS1655 4.9 66.7 1.0
N A:GLU1653 5.0 73.6 1.0
CG2 A:ILE1654 5.0 65.7 1.0

Zinc binding site 3 out of 4 in 7elc

Go back to Zinc Binding Sites List in 7elc
Zinc binding site 3 out of 4 in the Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn101

b:80.5
occ:1.00
SG B:CYS61 2.4 58.7 1.0
SG B:CYS58 2.4 59.0 1.0
SG B:CYS39 2.4 45.4 1.0
SG B:CYS42 2.4 44.4 1.0
CB B:CYS61 3.2 58.7 1.0
CB B:CYS58 3.2 59.0 1.0
CB B:CYS39 3.5 45.4 1.0
CB B:CYS42 3.5 44.4 1.0
NE B:ARG60 4.0 60.7 1.0
N B:CYS61 4.2 58.7 1.0
CA B:CYS61 4.2 58.7 1.0
N B:CYS42 4.3 44.4 1.0
CG B:ARG60 4.4 60.7 1.0
CA B:CYS58 4.5 59.0 1.0
CB B:ALA45 4.5 47.3 1.0
CA B:CYS42 4.5 44.4 1.0
N B:CYS58 4.6 59.0 1.0
CD B:ARG60 4.6 60.7 1.0
CZ B:ARG60 4.7 60.7 1.0
NH2 B:ARG60 4.8 60.7 1.0
CA B:CYS39 4.8 45.4 1.0

Zinc binding site 4 out of 4 in 7elc

Go back to Zinc Binding Sites List in 7elc
Zinc binding site 4 out of 4 in the Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of Monomeric Complex of Macv L Bound to Z and 3'-Vrna within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn102

b:84.7
occ:1.00
NE2 B:HIS55 2.0 60.9 1.0
CE1 B:HIS55 2.3 60.9 1.0
SG B:CYS75 2.4 52.9 1.0
SG B:CYS72 2.4 53.8 1.0
SG B:CYS52 2.4 68.6 1.0
CB B:CYS52 2.5 68.6 1.0
CD2 B:HIS55 3.3 60.9 1.0
ND1 B:HIS55 3.5 60.9 1.0
CB B:CYS75 3.5 52.9 1.0
CB B:CYS72 3.5 53.8 1.0
N B:CYS75 4.0 52.9 1.0
CG B:HIS55 4.0 60.9 1.0
CA B:CYS52 4.0 68.6 1.0
CA B:CYS75 4.4 52.9 1.0
N B:ASN53 4.4 72.1 1.0
CB B:ILE74 4.5 49.8 1.0
C B:CYS52 4.6 68.6 1.0
N B:CYS52 4.8 68.6 1.0
OD1 B:ASP54 4.8 69.9 1.0
CD2 B:LEU79 4.9 67.2 1.0
CA B:CYS72 4.9 53.8 1.0
CG2 B:ILE74 4.9 49.8 1.0
C B:ILE74 5.0 49.8 1.0

Reference:

R.Peng, X.Xu, Q.Peng, Y.Shi. Cryo-Em Structures of Lassa and Machupo Virus Polymerases Complexed with Cognate Regulatory Z Proteins Identify Targets For Antivirals. Nat Microbiol 2021.
ISSN: ESSN 2058-5276
Page generated: Tue Oct 29 19:55:36 2024

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