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Zinc in PDB 7ela: Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A)

Enzymatic activity of Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A)

All present enzymatic activity of Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A):
2.7.7.48;

Other elements in 7ela:

The structure of Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A) also contains other interesting chemical elements:

Manganese (Mn) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A) (pdb code 7ela). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A), PDB code: 7ela:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7ela

Go back to Zinc Binding Sites List in 7ela
Zinc binding site 1 out of 2 in the Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn101

b:122.3
occ:1.00
SG B:CYS53 2.4 71.7 1.0
SG B:CYS50 2.4 71.2 1.0
SG B:CYS31 2.4 59.3 1.0
SG B:CYS34 2.4 53.2 1.0
CB B:CYS53 3.1 71.7 1.0
CB B:CYS34 3.1 53.2 1.0
CB B:CYS50 3.3 71.2 1.0
CB B:CYS31 3.5 59.3 1.0
N B:CYS34 3.8 53.2 1.0
CA B:CYS34 4.0 53.2 1.0
O A:LYS691 4.0 49.5 1.0
CA B:CYS53 4.1 71.7 1.0
N B:CYS53 4.1 71.7 1.0
N B:CYS50 4.3 71.2 1.0
CA B:CYS50 4.4 71.2 1.0
C B:SER33 4.5 52.2 1.0
CG B:GLU37 4.7 72.3 1.0
CB B:SER33 4.7 52.2 1.0
CA B:CYS31 4.9 59.3 1.0
CB B:GLU37 5.0 72.3 1.0

Zinc binding site 2 out of 2 in 7ela

Go back to Zinc Binding Sites List in 7ela
Zinc binding site 2 out of 2 in the Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn102

b:112.6
occ:1.00
NE2 B:HIS47 2.3 74.8 1.0
SG B:CYS64 2.4 84.1 1.0
SG B:CYS67 2.4 90.0 1.0
SG B:CYS44 2.4 81.2 1.0
CD2 B:HIS47 2.9 74.8 1.0
CE1 B:HIS47 3.2 74.8 1.0
CB B:CYS44 3.2 81.2 1.0
CB B:CYS64 3.7 84.1 1.0
CB B:CYS67 3.9 90.0 1.0
CG B:HIS47 4.0 74.8 1.0
N B:CYS67 4.1 90.0 1.0
ND1 B:HIS47 4.1 74.8 1.0
CB B:ILE66 4.2 77.6 1.0
OD1 B:ASN46 4.4 81.7 1.0
CD1 B:LEU49 4.4 69.2 1.0
CA B:CYS67 4.6 90.0 1.0
CD2 B:LEU71 4.7 85.6 1.0
CA B:CYS44 4.7 81.2 1.0
CD1 B:ILE66 4.8 77.6 1.0
N B:ASN45 4.8 83.4 1.0
CG1 B:ILE66 4.9 77.6 1.0
CG2 B:ILE66 4.9 77.6 1.0
C B:ILE66 4.9 77.6 1.0
CA B:ILE66 5.0 77.6 1.0

Reference:

R.Peng, X.Xu, Q.Peng, Y.Shi. Cryo-Em Structures of Lassa and Machupo Virus Polymerases Complexed with Cognate Regulatory Z Proteins Identify Targets For Antivirals. Nat Microbiol 2021.
ISSN: ESSN 2058-5276
Page generated: Tue Oct 29 19:55:36 2024

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