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Zinc in PDB 7eds: Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic

Protein crystallography data

The structure of Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic, PDB code: 7eds was solved by Y.F.Xing, M.Lu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.88 / 1.77
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 137.53, 49.88, 33.95, 90, 93.31, 90
R / Rfree (%) 21 / 22.7

Other elements in 7eds:

The structure of Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic also contains other interesting chemical elements:

Arsenic (As) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic (pdb code 7eds). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic, PDB code: 7eds:

Zinc binding site 1 out of 1 in 7eds

Go back to Zinc Binding Sites List in 7eds
Zinc binding site 1 out of 1 in the Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn302

b:15.3
occ:1.00
ND1 A:HIS179 2.0 11.7 1.0
SG A:CYS242 2.2 17.1 1.0
SG A:CYS176 2.3 15.7 1.0
SG A:CYS238 2.4 16.8 1.0
CE1 A:HIS179 2.9 14.8 1.0
CB A:CYS242 3.0 16.8 1.0
CG A:HIS179 3.1 16.3 1.0
CB A:CYS238 3.3 16.8 1.0
CB A:CYS176 3.4 13.3 1.0
CB A:HIS179 3.4 17.0 1.0
CA A:CYS238 3.9 13.6 1.0
N A:CYS176 4.0 16.0 1.0
NE2 A:HIS179 4.1 16.1 1.0
CD2 A:HIS179 4.2 16.0 1.0
CA A:CYS176 4.3 17.0 1.0
N A:HIS179 4.4 17.0 1.0
CA A:CYS242 4.5 17.3 1.0
N A:ASN239 4.5 15.0 1.0
CA A:HIS179 4.6 16.1 1.0
O A:MET237 4.6 17.4 1.0
O A:HOH446 4.7 17.9 1.0
C A:CYS238 4.7 13.2 1.0
C A:CYS176 4.9 19.0 1.0
O A:CYS176 4.9 17.3 1.0

Reference:

Y.F.Xing, M.Lu. Arsenic-Bound P53 Hotspot Mutant M133T in Complex with the Natural PIG3 P53-Response Element To Be Published.
Page generated: Tue Oct 29 19:40:25 2024

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