Zinc in PDB 7ea5: Yeast SET2 Bound to A Nucleosome Containing Oncohistone Mutations

All present enzymatic activity of Yeast SET2 Bound to A Nucleosome Containing Oncohistone Mutations:
2.1.1.359;

The binding sites of Zinc atom in the Yeast SET2 Bound to A Nucleosome Containing Oncohistone Mutations (pdb code 7ea5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Yeast SET2 Bound to A Nucleosome Containing Oncohistone Mutations, PDB code: 7ea5:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Yeast SET2 Bound to A Nucleosome Containing Oncohistone Mutations


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Yeast SET2 Bound to A Nucleosome Containing Oncohistone Mutations within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn301 b:54.6 occ:1.00 SG K:CYS82 2.6 53.5 1.0 SG K:CYS105 2.7 58.0 1.0 SG K:CYS97 2.7 42.0 1.0 SG K:CYS109 3.0 57.6 1.0 CB K:CYS97 3.6 42.0 1.0 ZN K:ZN302 3.7 55.4 1.0 CB K:CYS109 4.0 57.6 1.0 CB K:CYS82 4.0 53.5 1.0 SG K:CYS68 4.0 49.2 1.0 CB K:CYS105 4.1 58.0 1.0 SG K:CYS102 4.4 52.6 1.0 SG K:CYS70 4.9 61.1 1.0

Zinc binding site 2 out of 3 in the Yeast SET2 Bound to A Nucleosome Containing Oncohistone Mutations


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Yeast SET2 Bound to A Nucleosome Containing Oncohistone Mutations within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn302 b:55.4 occ:1.00 CB K:CYS68 2.8 49.2 1.0 SG K:CYS68 2.9 49.2 1.0 SG K:CYS82 2.9 53.5 1.0 SG K:CYS70 2.9 61.1 1.0 SG K:CYS88 3.0 38.7 1.0 ZN K:ZN301 3.7 54.6 1.0 CB K:CYS88 3.9 38.7 1.0 CA K:CYS88 4.2 38.7 1.0 CB K:CYS70 4.3 61.1 1.0 CA K:CYS68 4.3 49.2 1.0 CB K:CYS82 4.3 53.5 1.0 SG K:CYS105 4.6 58.0 1.0 N K:CYS70 4.7 61.1 1.0 ND2 K:ASN90 4.7 33.8 1.0 N K:ASP69 4.8 49.0 1.0 N K:ILE89 4.8 30.4 1.0 C K:CYS88 4.9 38.7 1.0 CA K:CYS82 4.9 53.5 1.0 C K:CYS68 5.0 49.2 1.0

Zinc binding site 3 out of 3 in the Yeast SET2 Bound to A Nucleosome Containing Oncohistone Mutations


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Yeast SET2 Bound to A Nucleosome Containing Oncohistone Mutations within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn303 b:104.2 occ:1.00 SG K:CYS255 2.6 58.2 1.0 CB K:CYS248 2.6 69.0 1.0 SG K:CYS248 2.6 69.0 1.0 SG K:CYS250 3.4 62.6 1.0 SG K:CYS201 3.7 61.2 1.0 CB K:CYS255 4.0 58.2 1.0 CA K:CYS248 4.1 69.0 1.0 CD2 K:HIS199 4.5 64.6 1.0 CB K:CYS250 4.5 62.6 1.0 C K:CYS248 4.6 69.0 1.0 N K:GLY257 4.7 50.5 1.0 O K:PHE258 4.8 60.6 1.0 N K:CYS248 4.8 69.0 1.0 N K:CYS250 4.9 62.6 1.0 CA K:GLY257 4.9 50.5 1.0 N K:ILE256 5.0 50.6 1.0 NE2 K:HIS199 5.0 64.6 1.0

Y.Liu, Y.Zhang, H.Xue, M.Cao, G.Bai, Z.Mu, Y.Yao, S.Sun, D.Fang, J.Huang. Cryo-Em Structure of SETD2/SET2 Methyltransferase Bound to A Nucleosome Containing Oncohistone Mutations. Cell Discov V. 7 32 2021.
ISSN: ESSN 2056-5968
PubMed: 33972509
DOI: 10.1038/S41421-021-00261-6