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Zinc in PDB 7e8z: Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with SS81

Enzymatic activity of Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with SS81

All present enzymatic activity of Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with SS81:
1.14.11.53;

Protein crystallography data

The structure of Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with SS81, PDB code: 7e8z was solved by N.Y.Tam, Y.M.Ng, S.Shishodia, M.A.Mcdonough, C.J.Schofield, W.S.Aik, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.08 / 2.55
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 142.293, 142.293, 83.901, 90, 90, 120
R / Rfree (%) 19.5 / 23.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with SS81 (pdb code 7e8z). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with SS81, PDB code: 7e8z:

Zinc binding site 1 out of 1 in 7e8z

Go back to Zinc Binding Sites List in 7e8z
Zinc binding site 1 out of 1 in the Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with SS81


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with SS81 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn601

b:77.0
occ:0.90
 OD1 A:ASP233 2.1 68.2 1.0
O4 A:HZX602 2.2 62.1 0.7
N1 A:HZX602 2.2 73.9 0.7
NE2 A:HIS231 2.3 61.6 1.0
NE2 A:HIS307 2.3 64.9 1.0
C2 A:HZX602 2.5 69.5 0.7
C3 A:HZX602 2.6 74.9 0.7
CE1 A:HIS231 3.0 62.7 1.0
CG A:ASP233 3.1 68.9 1.0
CD2 A:HIS307 3.2 63.0 1.0
C4 A:HZX602 3.3 72.2 0.7
CE1 A:HIS307 3.3 62.4 1.0
OD2 A:ASP233 3.3 67.3 1.0
CD2 A:HIS231 3.5 65.5 1.0
N2 A:HZX602 3.6 74.0 0.7
N A:HZX602 3.7 71.3 0.7
C13 A:HZX602 3.9 76.5 0.7
ND1 A:HIS231 4.2 58.6 1.0
CG A:HIS307 4.4 58.5 1.0
C1 A:HZX602 4.4 63.1 0.7
ND1 A:HIS307 4.4 61.8 1.0
C11 A:HZX602 4.4 74.5 0.7
CG A:HIS231 4.5 58.1 1.0
CB A:ASP233 4.5 62.8 1.0
NH1 A:ARG322 4.6 63.4 1.0
C12 A:HZX602 4.6 79.8 0.7
O3 A:HZX602 4.8 73.2 0.7
CA A:ASP233 4.8 63.2 1.0
N A:ASP233 4.8 62.9 1.0
C5 A:HZX602 4.8 74.9 0.7

Reference:

S.Shishodia, M.Demetriades, D.Zhang, N.Y.Tam, P.Maheswaran, C.Clunie-O'connor, A.Tumber, I.K.H.Leung, Y.M.Ng, T.M.Leissing, A.H.El-Sagheer, E.Salah, T.Brown, W.S.Aik, M.A.Mcdonough, C.J.Schofield. Structure-Based Design of Selective Fat Mass- and Obesity-Associated Protein (Fto) Inhibitors J.Med.Chem. 2021.
ISSN: ISSN 0022-2623
DOI: 10.1021/ACS.JMEDCHEM.1C01204
Page generated: Thu Aug 21 23:52:24 2025

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