Zinc in PDB 7dp3: Human MCM8 N-Terminal Domain

All present enzymatic activity of Human MCM8 N-Terminal Domain:
3.6.4.12;

The structure of Human MCM8 N-Terminal Domain, PDB code: 7dp3 was solved by J.Li, L.Liu, Y.Liu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.65 / 2.55
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	46.017, 52.028, 137.221, 90, 91.86, 90
R / Rfree (%)	21.4 / 27.2

The binding sites of Zinc atom in the Human MCM8 N-Terminal Domain (pdb code 7dp3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human MCM8 N-Terminal Domain, PDB code: 7dp3:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human MCM8 N-Terminal Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human MCM8 N-Terminal Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn400 b:57.2 occ:1.00 SG A:CYS245 2.4 56.6 1.0 SG A:CYS264 2.5 56.9 1.0 SG A:CYS242 2.5 37.8 1.0 SG A:CYS269 2.7 100.8 1.0 CB A:CYS264 3.2 67.5 1.0 CB A:CYS242 3.2 41.7 1.0 N A:CYS245 3.6 63.0 1.0 CB A:CYS245 3.6 56.5 1.0 CG2 A:VAL266 3.9 74.8 1.0 CB A:ALA244 4.0 58.0 1.0 CA A:CYS245 4.2 59.7 1.0 CB A:CYS269 4.5 103.8 1.0 C A:ALA244 4.6 62.7 1.0 O A:CYS269 4.6 99.0 1.0 CA A:CYS242 4.7 48.0 1.0 CA A:ALA244 4.7 60.4 1.0 CA A:CYS264 4.7 72.5 1.0 CB A:GLU247 4.7 69.3 1.0 N A:ALA244 4.7 59.4 1.0 C A:CYS245 4.8 58.6 1.0 O A:HOH572 4.8 37.4 1.0 N A:GLY246 4.9 55.4 1.0 N A:GLY271 4.9 115.8 1.0 N A:GLU247 4.9 61.1 1.0 CG1 A:VAL266 4.9 70.4 1.0 O A:CYS242 4.9 53.8 1.0 C A:CYS242 4.9 51.0 1.0 C A:CYS269 5.0 99.7 1.0

Zinc binding site 2 out of 2 in the Human MCM8 N-Terminal Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human MCM8 N-Terminal Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn400 b:103.4 occ:1.00 SG B:CYS242 2.5 129.3 1.0 SG B:CYS245 2.7 102.4 1.0 SG B:CYS264 2.8 126.2 1.0 CB B:CYS269 3.2 150.4 1.0 SG B:CYS269 3.2 152.6 1.0 CB B:CYS245 3.7 108.2 1.0 CB B:CYS242 3.7 128.5 1.0 N B:CYS245 4.2 120.7 1.0 CB B:ALA244 4.2 96.4 1.0 CA B:CYS245 4.6 116.2 1.0 CB B:CYS264 4.6 125.0 1.0 C B:ALA244 4.6 99.8 1.0 O B:HOH507 4.6 64.5 1.0 CA B:CYS269 4.7 147.3 1.0 O B:CYS264 4.7 116.7 1.0 CA B:ALA244 4.8 100.2 1.0 CA B:ARG270 4.9 120.9 1.0 N B:GLY271 4.9 97.7 1.0 N B:ALA244 5.0 102.4 1.0

J.Li, L.Liu, Y.Liu. Human MCM8 N-Terminal Domain To Be Published.