Zinc in PDB 7cq3: Crystal Structure of SLX1-SLX4

The structure of Crystal Structure of SLX1-SLX4, PDB code: 7cq3 was solved by X.Xu, M.Wang, J.Sun, G.Li, N.Yang, R.M.Xu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.82 / 1.45
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	70.3, 118.421, 62.002, 90, 90, 90
R / Rfree (%)	12.3 / 15.7

The binding sites of Zinc atom in the Crystal Structure of SLX1-SLX4 (pdb code 7cq3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of SLX1-SLX4, PDB code: 7cq3:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of SLX1-SLX4


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of SLX1-SLX4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:16.2 occ:1.00 ND1 A:HIS251 2.1 15.7 1.0 SG A:CYS221 2.3 17.2 1.0 SG A:CYS218 2.3 16.1 1.0 SG A:CYS254 2.3 16.0 1.0 CB A:CYS218 3.0 17.5 1.0 CE1 A:HIS251 3.1 17.4 1.0 CG A:HIS251 3.1 14.2 1.0 CB A:CYS221 3.3 17.1 1.0 CB A:CYS254 3.3 14.0 1.0 CB A:HIS251 3.4 14.1 1.0 O A:HOH942 3.7 41.7 1.0 N A:CYS221 3.8 17.2 1.0 CA A:CYS221 4.1 17.2 1.0 N A:HIS251 4.1 13.3 1.0 NE2 A:HIS251 4.2 16.5 1.0 CD2 A:HIS251 4.2 15.1 1.0 O A:HOH953 4.2 28.1 1.0 CA A:HIS251 4.4 13.9 1.0 CA A:CYS218 4.5 16.4 1.0 CA A:CYS254 4.7 13.5 1.0 CB A:ILE220 4.8 15.5 1.0 C A:CYS221 4.9 18.3 1.0 C A:ILE220 4.9 17.7 1.0 O A:HOH1074 5.0 32.2 1.0 N A:GLU222 5.0 18.2 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of SLX1-SLX4


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of SLX1-SLX4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:21.2 occ:1.00 SG A:CYS241 2.3 19.6 1.0 SG A:CYS282 2.3 22.0 1.0 SG A:CYS279 2.3 18.4 1.0 SG A:CYS246 2.3 22.4 1.0 CB A:CYS279 3.1 17.2 1.0 CB A:CYS246 3.1 25.2 1.0 CB A:CYS241 3.2 16.8 1.0 CB A:CYS282 3.3 24.3 1.0 N A:CYS282 3.7 23.1 1.0 CA A:CYS282 4.1 24.5 1.0 SG A:CYS248 4.1 21.2 1.0 CB A:ASN243 4.5 24.6 1.0 CA A:CYS246 4.5 26.6 1.0 CA A:CYS279 4.6 17.1 1.0 O A:HOH794 4.6 31.4 1.0 CB A:LYS281 4.6 23.2 1.0 CA A:CYS241 4.6 16.6 1.0 O A:HOH973 4.7 19.4 1.0 ND2 A:ASN243 4.8 27.2 1.0 C A:LYS281 4.8 24.4 1.0 N A:GLY247 4.8 25.1 1.0 C A:CYS282 4.8 24.1 1.0 N A:LYS281 5.0 21.0 1.0 C A:CYS246 5.0 26.8 1.0 N A:ASP283 5.0 22.2 1.0 CA A:LYS281 5.0 23.4 1.0

X.Xu, M.Wang, J.Sun, G.Li, N.Yang, R.M.Xu. Structural Insights Into Substrate Dna Recognition By the SLX1-SLX4 Endonuclease Complex To Be Published.