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Zinc in PDB 7auc: Crystal Structure of An Engineered Helicase Domain Construct For Human Bloom Syndrome Protein (Blm)

Enzymatic activity of Crystal Structure of An Engineered Helicase Domain Construct For Human Bloom Syndrome Protein (Blm)

All present enzymatic activity of Crystal Structure of An Engineered Helicase Domain Construct For Human Bloom Syndrome Protein (Blm):
3.6.4.12;

Protein crystallography data

The structure of Crystal Structure of An Engineered Helicase Domain Construct For Human Bloom Syndrome Protein (Blm), PDB code: 7auc was solved by X.Chen, A.W.Oliver, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 51.23 / 1.53
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 54.280, 107.690, 55.200, 90.00, 109.31, 90.00
R / Rfree (%) 18.9 / 20.8

Other elements in 7auc:

The structure of Crystal Structure of An Engineered Helicase Domain Construct For Human Bloom Syndrome Protein (Blm) also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Calcium (Ca) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of An Engineered Helicase Domain Construct For Human Bloom Syndrome Protein (Blm) (pdb code 7auc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of An Engineered Helicase Domain Construct For Human Bloom Syndrome Protein (Blm), PDB code: 7auc:

Zinc binding site 1 out of 1 in 7auc

Go back to Zinc Binding Sites List in 7auc
Zinc binding site 1 out of 1 in the Crystal Structure of An Engineered Helicase Domain Construct For Human Bloom Syndrome Protein (Blm)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of An Engineered Helicase Domain Construct For Human Bloom Syndrome Protein (Blm) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1517

b:26.1
occ:1.00
 SG A:CYS1055 2.3 27.1 1.0
SG A:CYS1066 2.4 28.1 1.0
SG A:CYS1036 2.4 26.0 1.0
SG A:CYS1063 2.5 25.1 1.0
CB A:CYS1055 3.2 29.6 1.0
CB A:CYS1036 3.2 24.9 1.0
CB A:CYS1066 3.3 30.5 1.0
CB A:CYS1063 3.5 22.4 1.0
CA A:CYS1036 3.6 24.3 1.0
N A:CYS1063 3.9 24.8 1.0
N A:ARG1037 4.0 22.1 1.0
O A:HOH1833 4.1 31.9 1.0
C A:CYS1036 4.2 22.8 1.0
CA A:CYS1063 4.3 23.1 1.0
N A:CYS1066 4.3 30.3 1.0
CA A:CYS1066 4.4 32.3 1.0
CA A:CYS1055 4.5 29.8 1.0
N A:ARG1038 4.6 20.9 1.0
CG A:ARG1038 4.6 22.9 1.0
CD A:ARG1038 4.6 23.3 1.0
O A:CYS1063 4.8 25.3 1.0
N A:CYS1055 4.8 29.2 1.0
OG A:SER1062 4.9 29.0 1.0
C A:CYS1063 4.9 24.5 1.0
NE A:ARG1038 4.9 22.2 1.0
N A:CYS1036 5.0 24.5 1.0

Reference:

X.Chen, Y.Ali, C.E.L.Fisher, R.Arribas-Bosacoma, M.B.Rajasekaran, G.Williams, S.Walker, S.M.Roe, L.H.Pearl, S.E.Ward, F.M.G.Pearl, A.W.Oliver. Uncovering An Allosteric Mode of Action For A Selective Inhibitor of Human Bloom Syndrome Protein Biorxiv 2020.
DOI: 10.1101/2020.11.30.403493
Page generated: Thu Aug 21 22:35:20 2025

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