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Zinc in PDB 7adn: Apo Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant

Enzymatic activity of Apo Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant

All present enzymatic activity of Apo Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant:
2.4.2.29;

Protein crystallography data

The structure of Apo Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant, PDB code: 7adn was solved by D.Nguyen, S.You, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.85 / 1.92
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 127.864, 127.864, 115.486, 90, 90, 120
R / Rfree (%) 17.2 / 18.8

Zinc Binding Sites:

The binding sites of Zinc atom in the Apo Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant (pdb code 7adn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Apo Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant, PDB code: 7adn:

Zinc binding site 1 out of 1 in 7adn

Go back to Zinc Binding Sites List in 7adn
Zinc binding site 1 out of 1 in the Apo Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Apo Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:24.4
occ:1.00
ND1 A:HIS349 2.1 24.3 1.0
SG A:CYS320 2.3 23.5 1.0
SG A:CYS318 2.3 25.0 1.0
SG A:CYS323 2.3 24.9 1.0
CE1 A:HIS349 3.0 26.3 1.0
CG A:HIS349 3.2 21.6 1.0
CB A:CYS318 3.3 24.4 1.0
CB A:CYS323 3.3 25.3 1.0
CB A:CYS320 3.3 22.3 1.0
CB A:HIS349 3.6 20.5 1.0
N A:CYS323 3.9 23.1 1.0
CA A:HIS349 4.1 19.6 1.0
N A:CYS320 4.1 26.5 1.0
NE2 A:HIS349 4.2 22.3 1.0
CA A:CYS323 4.2 26.0 1.0
CA A:CYS320 4.2 25.0 1.0
CD2 A:HIS349 4.3 21.8 1.0
O A:HIS349 4.5 22.6 1.0
CA A:CYS318 4.6 22.1 1.0
C A:CYS318 4.7 26.7 1.0
C A:CYS320 4.7 28.3 1.0
C A:HIS349 4.7 19.9 1.0
O A:CYS320 4.8 24.1 1.0
CB A:VAL322 4.8 22.9 1.0
O A:CYS318 4.8 26.0 1.0
C A:VAL322 4.9 24.8 1.0

Reference:

D.Nguyen, X.Xie, S.Jakobi, F.Terwesten, A.Metz, T.X.P.Nguyen, V.A.Palchykov, A.Heine, K.Reuter, G.Klebe. Targeting A Cryptic Pocket in A Protein-Protein Contact By Disulfide-Induced Rupture of A Homodimeric Interface Acs Chem.Biol. 2021.
ISSN: ESSN 1554-8937
DOI: 10.1021/ACSCHEMBIO.1C00296
Page generated: Tue Oct 29 16:40:12 2024

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