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Zinc in PDB 7a1q: Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3- (Carboxycarbonyl)Cyclopentane-1-Carboxylic Acid, and Consensus Ankyrin Repeat Domain (20-Mer)

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3- (Carboxycarbonyl)Cyclopentane-1-Carboxylic Acid, and Consensus Ankyrin Repeat Domain (20-Mer)

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3- (Carboxycarbonyl)Cyclopentane-1-Carboxylic Acid, and Consensus Ankyrin Repeat Domain (20-Mer):
1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3- (Carboxycarbonyl)Cyclopentane-1-Carboxylic Acid, and Consensus Ankyrin Repeat Domain (20-Mer), PDB code: 7a1q was solved by Y.Nakashima, L.Brewitz, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.12 / 1.75
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 85.968, 85.968, 148.177, 90, 90, 90
R / Rfree (%) 17.7 / 20

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3- (Carboxycarbonyl)Cyclopentane-1-Carboxylic Acid, and Consensus Ankyrin Repeat Domain (20-Mer) (pdb code 7a1q). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3- (Carboxycarbonyl)Cyclopentane-1-Carboxylic Acid, and Consensus Ankyrin Repeat Domain (20-Mer), PDB code: 7a1q:

Zinc binding site 1 out of 1 in 7a1q

Go back to Zinc Binding Sites List in 7a1q
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3- (Carboxycarbonyl)Cyclopentane-1-Carboxylic Acid, and Consensus Ankyrin Repeat Domain (20-Mer)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3- (Carboxycarbonyl)Cyclopentane-1-Carboxylic Acid, and Consensus Ankyrin Repeat Domain (20-Mer) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:38.8
occ:1.00
 O05 A:QVQ505 2.0 61.0 1.0
OD2 A:ASP201 2.0 64.9 1.0
NE2 A:HIS199 2.1 50.6 1.0
O03 A:QVQ505 2.1 74.3 1.0
NE2 A:HIS279 2.1 43.2 1.0
C08 A:QVQ505 2.7 65.3 1.0
C02 A:QVQ505 2.8 68.2 1.0
CG A:ASP201 2.9 50.0 1.0
CE1 A:HIS199 3.0 46.8 1.0
CE1 A:HIS279 3.0 39.4 1.0
CD2 A:HIS199 3.1 44.6 1.0
HE1 A:HIS279 3.1 47.3 1.0
CD2 A:HIS279 3.1 42.6 1.0
HE1 A:HIS199 3.2 56.2 1.0
OD1 A:ASP201 3.2 38.6 1.0
HD2 A:HIS199 3.3 53.6 1.0
HD2 A:HIS279 3.4 51.2 1.0
HZ2 A:TRP296 3.4 55.0 1.0
HB2 B:ASN16 3.7 52.0 1.0
O A:HOH667 3.9 38.8 1.0
O04 A:QVQ505 4.0 71.1 1.0
ND1 A:HIS199 4.1 43.6 1.0
ND1 A:HIS279 4.1 37.7 1.0
CG A:HIS199 4.1 41.3 1.0
CG A:HIS279 4.2 38.3 1.0
CB A:ASP201 4.3 38.3 1.0
C07 A:QVQ505 4.3 59.3 1.0
CZ2 A:TRP296 4.3 45.8 1.0
HB2 A:ASP201 4.4 46.0 1.0
HD22 A:ASN205 4.4 51.3 1.0
H B:ASN16 4.4 53.2 1.0
CB B:ASN16 4.6 43.3 1.0
HE1 A:TRP296 4.6 49.4 1.0
CG B:ASN16 4.6 41.5 1.0
HD22 B:ASN16 4.7 49.8 1.0
ND2 B:ASN16 4.7 41.4 1.0
H07 A:QVQ505 4.7 85.4 1.0
H03 A:QVQ505 4.8 63.4 1.0
H08 A:QVQ505 4.8 83.6 1.0
HD1 A:HIS199 4.8 52.4 1.0
HB3 A:ASP201 4.9 46.0 1.0
HD1 A:HIS279 4.9 45.3 1.0
H10 A:QVQ505 4.9 71.2 1.0
N A:ASP201 4.9 38.5 1.0
H A:ASP201 5.0 46.3 1.0
C06 A:QVQ505 5.0 69.6 1.0

Reference:

Y.Nakashima, L.Brewitz, C.J.Schofield. 2-Oxoglutarate Derivatives Modulate the Catalytic Activity of Human Factor Inhibiting Hif-Alpha To Be Published.
Page generated: Tue Oct 29 16:17:16 2024

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