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Zinc in PDB 7a1n: Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer)

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer)

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer):
1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer), PDB code: 7a1n was solved by Y.Nakashima, L.Brewitz, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.27 / 2.01
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.052, 86.052, 147.833, 90, 90, 90
R / Rfree (%) 21.3 / 23.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer) (pdb code 7a1n). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer), PDB code: 7a1n:

Zinc binding site 1 out of 1 in 7a1n

Go back to Zinc Binding Sites List in 7a1n
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1007

b:46.4
occ:1.00
 O01 A:ROQ1008 1.9 60.1 1.0
OD2 A:ASP201 2.0 60.4 1.0
NE2 A:HIS279 2.1 86.6 1.0
NE2 A:HIS199 2.1 88.3 1.0
O03 A:ROQ1008 2.4 62.6 1.0
C01 A:ROQ1008 2.7 61.5 1.0
CE1 A:HIS199 3.0 71.2 1.0
C05 A:ROQ1008 3.0 64.2 1.0
CD2 A:HIS279 3.0 74.4 1.0
CG A:ASP201 3.0 57.4 1.0
CE1 A:HIS279 3.1 70.3 1.0
HE1 A:HIS199 3.1 85.5 1.0
CD2 A:HIS199 3.2 72.7 1.0
HD2 A:HIS279 3.2 89.3 1.0
HE1 A:HIS279 3.2 84.4 1.0
OD1 A:ASP201 3.4 55.4 1.0
HD2 A:HIS199 3.4 87.3 1.0
HZ2 A:TRP296 3.5 65.7 1.0
O A:HOH1117 3.7 42.4 1.0
HB2 B:ASN16 3.8 60.3 1.0
ND1 A:HIS199 4.1 70.5 1.0
C02 A:ROQ1008 4.1 74.4 1.0
ND1 A:HIS279 4.1 70.9 1.0
CG A:HIS279 4.2 62.3 1.0
CG A:HIS199 4.2 63.6 1.0
H04 A:ROQ1008 4.3 103.8 1.0
O02 A:ROQ1008 4.3 62.1 1.0
HD22 A:ASN205 4.3 57.1 1.0
CB A:ASP201 4.4 52.9 1.0
CZ2 A:TRP296 4.4 54.7 1.0
HB2 A:ASP201 4.4 63.5 1.0
HE1 A:TRP296 4.6 65.4 1.0
H B:ASN16 4.7 59.5 1.0
C04 A:ROQ1008 4.7 86.4 1.0
H02 A:ROQ1008 4.7 81.5 1.0
CB B:ASN16 4.7 50.6 1.0
H01 A:ROQ1008 4.7 89.3 1.0
CG B:ASN16 4.7 49.7 1.0
HD22 B:ASN16 4.8 59.7 1.0
ND2 B:ASN16 4.8 50.1 1.0
HD1 A:HIS199 4.8 84.6 1.0
H03 A:ROQ1008 4.9 81.5 1.0
C03 A:ROQ1008 4.9 67.8 1.0
HD1 A:HIS279 4.9 85.2 1.0
ND2 A:ASN205 5.0 47.5 1.0
HB3 A:ASP201 5.0 63.5 1.0
HD21 A:ASN205 5.0 57.1 1.0

Reference:

Y.Nakashima, L.Brewitz, C.J.Schofield. 2-Oxoglutarate Derivatives Modulate the Catalytic Activity of Human Factor Inhibiting Hif-Alpha To Be Published.
Page generated: Tue Oct 29 16:16:26 2024

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