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Zinc in PDB 6zn5: Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2

Enzymatic activity of Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2

All present enzymatic activity of Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13; 4.2.99.18;

Zinc Binding Sites:

The binding sites of Zinc atom in the Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2 (pdb code 6zn5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2, PDB code: 6zn5:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in 6zn5

Go back to Zinc Binding Sites List in 6zn5
Zinc binding site 1 out of 3 in the Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
c:Zn201

b:60.4
occ:1.00
SG c:CYS74 2.5 38.0 1.0
CB c:CYS26 2.5 42.1 1.0
SG c:CYS23 2.6 43.1 1.0
CB c:CYS74 3.0 38.0 1.0
SG c:CYS77 3.3 40.6 1.0
CB c:CYS77 3.4 40.6 1.0
CB c:CYS23 3.4 43.1 1.0
N c:CYS26 3.5 42.1 1.0
CA c:CYS26 3.6 42.1 1.0
SG c:CYS26 3.6 42.1 1.0
N c:CYS74 3.9 38.0 1.0
CA c:CYS74 4.0 38.0 1.0
N c:CYS77 4.3 40.6 1.0
CA c:CYS77 4.4 40.6 1.0
C c:CYS26 4.5 42.1 1.0
N c:ALA27 4.6 40.8 1.0
CB c:ARG28 4.7 41.6 1.0
C c:ASN25 4.8 43.6 1.0
C c:CYS74 4.8 38.0 1.0
CA c:CYS23 4.8 43.1 1.0
OD1 c:ASN25 4.9 43.6 1.0

Zinc binding site 2 out of 3 in 6zn5

Go back to Zinc Binding Sites List in 6zn5
Zinc binding site 2 out of 3 in the Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
f:Zn201

b:15.7
occ:1.00
SG f:CYS21 2.4 8.0 1.0
SG f:CYS24 2.4 11.8 1.0
CB f:CYS39 2.4 16.5 1.0
CB f:CYS24 2.6 11.8 1.0
CB f:CYS21 3.2 8.0 1.0
SG f:CYS39 3.4 16.5 1.0
CB f:CYS42 3.5 19.4 1.0
CA f:CYS39 3.6 16.5 1.0
N f:CYS39 3.6 16.5 1.0
SG f:CYS42 3.6 19.4 1.0
N f:CYS24 3.7 11.8 1.0
CA f:CYS24 3.7 11.8 1.0
CG1 f:VAL23 4.5 12.6 1.0
N f:CYS42 4.5 19.4 1.0
CA f:CYS42 4.6 19.4 1.0
CA f:CYS21 4.6 8.0 1.0
C f:CYS39 4.7 16.5 1.0
C f:CYS24 4.7 11.8 1.0
CB f:ASN26 4.7 9.6 1.0
O2' 2:G1495 4.8 9.0 1.0
C f:VAL23 4.8 12.6 1.0
C f:MET38 4.8 11.2 1.0

Zinc binding site 3 out of 3 in 6zn5

Go back to Zinc Binding Sites List in 6zn5
Zinc binding site 3 out of 3 in the Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex - State 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
g:Zn500

b:74.8
occ:1.00
OE2 g:GLU125 2.1 56.5 1.0
OE1 g:GLU125 2.4 56.5 1.0
CD g:GLU125 2.4 56.5 1.0
CG g:LYS143 2.5 57.1 1.0
CD g:LYS143 2.6 57.1 1.0
CB g:CYS126 2.6 53.7 1.0
CE g:LYS143 2.8 57.1 1.0
CB g:LYS143 3.1 57.1 1.0
CA g:CYS126 3.4 53.7 1.0
NZ g:LYS143 3.6 57.1 1.0
SG g:CYS126 3.7 53.7 1.0
CG g:GLU125 3.7 56.5 1.0
N g:CYS126 3.7 53.7 1.0
O g:GLU125 3.8 56.5 1.0
C g:GLU125 3.9 56.5 1.0
CB g:GLU125 4.4 56.5 1.0
CG2 g:VAL130 4.5 54.2 1.0
CA g:LYS143 4.5 57.1 1.0
CG1 g:VAL130 4.5 54.2 1.0
CB g:VAL130 4.7 54.2 1.0
CA g:GLU125 4.8 56.5 1.0
C g:CYS126 4.9 53.7 1.0

Reference:

M.Thoms, R.Buschauer, M.Ameismeier, L.Koepke, T.Denk, M.Hirschenberger, H.Kratzat, M.Hayn, T.Mackens-Kiani, J.Cheng, J.H.Straub, C.M.Sturzel, T.Frohlich, O.Berninghausen, T.Becker, F.Kirchhoff, K.M.J.Sparrer, R.Beckmann. Structural Basis For Translational Shutdown and Immune Evasion By the NSP1 Protein of Sars-Cov-2. Science V. 369 1249 2020.
ISSN: ESSN 1095-9203
PubMed: 32680882
DOI: 10.1126/SCIENCE.ABC8665
Page generated: Tue Oct 29 15:47:12 2024

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