Zinc in PDB 6y5e: Structure of Human Cgas (K394E) Bound to the Nucleosome (Focused Refinement of Cgas-Ncp Subcomplex)

All present enzymatic activity of Structure of Human Cgas (K394E) Bound to the Nucleosome (Focused Refinement of Cgas-Ncp Subcomplex):
2.7.7.86;

The binding sites of Zinc atom in the Structure of Human Cgas (K394E) Bound to the Nucleosome (Focused Refinement of Cgas-Ncp Subcomplex) (pdb code 6y5e). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Human Cgas (K394E) Bound to the Nucleosome (Focused Refinement of Cgas-Ncp Subcomplex), PDB code: 6y5e:

Zinc binding site 1 out of 1 in the Structure of Human Cgas (K394E) Bound to the Nucleosome (Focused Refinement of Cgas-Ncp Subcomplex)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human Cgas (K394E) Bound to the Nucleosome (Focused Refinement of Cgas-Ncp Subcomplex) within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn601 b:0.0 occ:1.01 NE2 K:HIS390 2.0 0.0 0.0 SG K:CYS404 2.3 0.0 0.0 SG K:CYS396 2.3 21.3 0.0 SG K:CYS397 2.3 21.8 0.0 CD2 K:HIS390 2.9 0.0 0.0 CE1 K:HIS390 3.0 0.0 0.0 CB K:CYS404 3.4 0.0 0.0 CB K:CYS396 3.4 22.9 0.0 CB K:CYS397 3.7 24.5 0.0 C K:CYS396 3.9 20.8 1.0 N K:CYS397 3.9 16.2 1.0 N K:CYS404 3.9 0.0 1.0 CG K:HIS390 4.0 0.0 0.0 ND1 K:HIS390 4.1 0.0 0.0 O K:GLU402 4.1 0.0 1.0 O K:CYS396 4.2 20.2 1.0 CA K:CYS404 4.2 0.0 1.0 CA K:CYS396 4.2 22.6 1.0 CA K:CYS397 4.4 18.6 1.0 O K:CYS404 4.5 0.0 1.0 C K:CYS404 4.6 0.0 1.0 NH1 K:ARG406 4.6 0.0 0.0

G.R.Pathare, A.Decout, S.Gluck, S.Cavadini, K.Makasheva, R.Hovius, G.Kempf, J.Weiss, Z.Kozicka, B.Guey, P.Melenec, B.Fierz, N.H.Thoma, A.Ablasser. Structural Mechanism of Cgas Inhibition By the Nucleosome. Nature V. 587 668 2020.
ISSN: ESSN 1476-4687
PubMed: 32911482
DOI: 10.1038/S41586-020-2750-6