Zinc in PDB 6vvx: Mycobacterium Tuberculosis Wt Rnap Transcription Initiation Intermediate Structure with Sorangicin

All present enzymatic activity of Mycobacterium Tuberculosis Wt Rnap Transcription Initiation Intermediate Structure with Sorangicin:
2.7.7.6;

The structure of Mycobacterium Tuberculosis Wt Rnap Transcription Initiation Intermediate Structure with Sorangicin also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Mycobacterium Tuberculosis Wt Rnap Transcription Initiation Intermediate Structure with Sorangicin (pdb code 6vvx). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Mycobacterium Tuberculosis Wt Rnap Transcription Initiation Intermediate Structure with Sorangicin, PDB code: 6vvx:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Mycobacterium Tuberculosis Wt Rnap Transcription Initiation Intermediate Structure with Sorangicin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Mycobacterium Tuberculosis Wt Rnap Transcription Initiation Intermediate Structure with Sorangicin within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2000 b:0.9 occ:1.00 SG D:CYS891 2.4 0.6 1.0 SG D:CYS978 2.4 0.2 1.0 SG D:CYS975 2.5 0.3 1.0 SG D:CYS968 2.5 0.6 1.0 CB D:CYS975 3.0 0.3 1.0 CB D:CYS891 3.1 0.6 1.0 CB D:CYS968 3.1 0.6 1.0 CB D:CYS978 3.2 0.2 1.0 CA D:CYS968 3.6 0.6 1.0 N D:CYS975 3.7 0.3 1.0 CA D:CYS975 3.9 0.3 1.0 N D:ALA969 4.0 0.3 1.0 N D:CYS891 4.2 0.6 1.0 CA D:CYS891 4.3 0.6 1.0 N D:CYS978 4.3 0.2 1.0 C D:CYS968 4.3 0.6 1.0 CA D:CYS978 4.3 0.2 1.0 C D:CYS975 4.5 0.3 1.0 O D:CYS975 4.7 0.3 1.0 OG1 D:THR970 4.8 0.5 1.0 N D:CYS968 4.8 0.6 1.0 NH1 D:ARG963 4.9 0.6 1.0 C D:VAL974 4.9 1.0 1.0 N D:THR970 4.9 0.5 1.0 OG1 D:THR977 5.0 0.6 1.0 CG2 D:THR970 5.0 0.5 1.0

Zinc binding site 2 out of 2 in the Mycobacterium Tuberculosis Wt Rnap Transcription Initiation Intermediate Structure with Sorangicin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Mycobacterium Tuberculosis Wt Rnap Transcription Initiation Intermediate Structure with Sorangicin within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2001 b:0.0 occ:1.00 N D:CYS62 2.2 0.2 1.0 SG D:CYS78 2.5 0.2 1.0 SG D:CYS60 2.5 0.9 1.0 SG D:CYS62 2.5 0.2 1.0 N D:TYR61 2.6 0.0 1.0 CB D:CYS60 2.7 0.9 1.0 CB D:CYS78 3.1 0.2 1.0 C D:CYS60 3.1 0.9 1.0 C D:TYR61 3.1 0.0 1.0 CA D:CYS62 3.1 0.2 1.0 CB D:CYS62 3.2 0.2 1.0 CA D:TYR61 3.3 0.0 1.0 N D:GLY63 3.4 0.3 1.0 CA D:CYS60 3.4 0.9 1.0 C D:CYS62 3.7 0.2 1.0 O D:CYS60 3.9 0.9 1.0 CB D:TYR61 3.9 0.0 1.0 SG D:CYS75 4.0 0.1 1.0 O D:TYR61 4.2 0.0 1.0 CB D:CYS75 4.3 0.1 1.0 CA D:CYS78 4.4 0.2 1.0 N D:LYS64 4.5 0.6 1.0 CA D:GLY63 4.6 0.3 1.0 N D:CYS78 4.6 0.2 1.0 N D:CYS60 4.6 0.9 1.0 O D:CYS62 4.9 0.2 1.0

M.Lilic, J.Chen, H.Boyaci, N.Braffman, E.A.Hubin, J.Herrmann, R.Muller, R.Mooney, R.Landick, S.A.Darst, E.A.Campbell. The Antibiotic Sorangicin A Inhibits Promoter Dna Unwinding in A Mycobacterium Tuberculosis Rifampicin-Resistant Rna Polymerase. Proc.Natl.Acad.Sci.Usa 2020.
ISSN: ESSN 1091-6490
PubMed: 33199626
DOI: 10.1073/PNAS.2013706117