Zinc in PDB 6tay: Mouse RNF213 Mutant R4753K Modeling the Moyamoya-Disease-Related Human Variant R4810K

All present enzymatic activity of Mouse RNF213 Mutant R4753K Modeling the Moyamoya-Disease-Related Human Variant R4810K:
2.3.2.27;

The structure of Mouse RNF213 Mutant R4753K Modeling the Moyamoya-Disease-Related Human Variant R4810K also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Mouse RNF213 Mutant R4753K Modeling the Moyamoya-Disease-Related Human Variant R4810K (pdb code 6tay). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Mouse RNF213 Mutant R4753K Modeling the Moyamoya-Disease-Related Human Variant R4810K, PDB code: 6tay:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Mouse RNF213 Mutant R4753K Modeling the Moyamoya-Disease-Related Human Variant R4810K


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Mouse RNF213 Mutant R4753K Modeling the Moyamoya-Disease-Related Human Variant R4810K within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn5203 b:0.4 occ:1.00 ND1 A:HIS3964 2.2 0.8 1.0 SG A:CYS3982 2.4 0.7 1.0 SG A:CYS3962 2.4 0.1 1.0 SG A:CYS3985 2.4 0.0 1.0 CE1 A:HIS3964 2.9 0.8 1.0 CG A:HIS3964 3.1 0.8 1.0 CB A:CYS3982 3.4 0.7 1.0 CB A:CYS3962 3.6 0.1 1.0 CB A:HIS3964 3.6 0.8 1.0 CB A:CYS3985 3.7 0.0 1.0 NE2 A:HIS3964 3.9 0.8 1.0 N A:CYS3985 4.0 0.0 1.0 CD2 A:HIS3964 4.1 0.8 1.0 O A:CYS3962 4.3 0.1 1.0 CA A:CYS3985 4.4 0.0 1.0 OH A:TYR3966 4.5 0.6 1.0 CD2 A:LEU3960 4.5 0.9 1.0 C A:CYS3962 4.7 0.1 1.0 CA A:CYS3962 4.8 0.1 1.0 CB A:TYR3984 4.8 0.5 1.0 CA A:CYS3982 4.9 0.7 1.0 CA A:HIS3964 5.0 0.8 1.0 C A:CYS3985 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Mouse RNF213 Mutant R4753K Modeling the Moyamoya-Disease-Related Human Variant R4810K


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Mouse RNF213 Mutant R4753K Modeling the Moyamoya-Disease-Related Human Variant R4810K within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn5204 b:0.6 occ:1.00 SG A:CYS3967 2.5 0.7 1.0 SG A:CYS3950 2.5 0.8 1.0 SG A:CYS3947 2.5 96.2 0.5 SG A:CYS3970 2.5 0.8 1.0 CB A:CYS3950 3.0 0.8 1.0 CB A:CYS3967 3.1 0.7 1.0 CB A:CYS3947 3.1 96.2 0.5 N A:CYS3950 3.4 0.8 1.0 CB A:CYS3970 3.5 0.8 1.0 CA A:CYS3950 3.8 0.8 1.0 N A:CYS3967 3.9 0.7 1.0 CA A:CYS3967 4.1 0.7 1.0 CB A:ILE3949 4.5 0.0 1.0 CA A:CYS3947 4.6 96.2 0.5 C A:ILE3949 4.6 0.0 1.0 C A:CYS3950 4.8 0.8 1.0 CA A:CYS3970 4.8 0.8 1.0 N A:ILE3949 4.8 0.0 1.0 NH2 A:ARG3969 4.8 0.2 1.0 CA A:ILE3949 4.9 0.0 1.0 C A:CYS3947 5.0 96.2 0.5

J.Ahel, A.Lehner, A.Vogel, A.Schleiffer, A.Meinhart, D.Haselbach, T.Clausen. Cryo-Em Structure of RNF213 Reveals A Ring-Type E3 with A Dynein Core and Cysteine Reactivity To Be Published.