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Zinc in PDB 6pw8: Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (Fak)

Enzymatic activity of Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (Fak)

All present enzymatic activity of Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (Fak):
2.7.10.2;

Protein crystallography data

The structure of Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (Fak), PDB code: 6pw8 was solved by D.G.Thifault, P.Fromme, J.M.Martin-Garcia, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.66 / 1.95
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 47.489, 53.094, 53.419, 90.00, 90.00, 90.00
R / Rfree (%) 21.7 / 25

Other elements in 6pw8:

The structure of Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (Fak) also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (Fak) (pdb code 6pw8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (Fak), PDB code: 6pw8:

Zinc binding site 1 out of 1 in 6pw8

Go back to Zinc Binding Sites List in 6pw8
Zinc binding site 1 out of 1 in the Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (Fak)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (Fak) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1101

b:30.7
occ:1.00
 O A:HOH1216 1.9 31.7 1.0
OE2 A:GLU956 1.9 30.8 1.0
OE1 A:GLU937 2.0 30.2 1.0
CD A:GLU956 2.6 27.7 1.0
CD A:GLU937 2.7 35.8 1.0
OE1 A:GLU956 2.7 28.5 1.0
OE2 A:GLU937 2.8 37.7 1.0
CG A:GLU956 4.1 27.9 1.0
O A:HOH1211 4.1 36.8 1.0
CG A:GLU937 4.2 35.0 1.0
NZ A:LYS933 4.3 37.0 1.0
CA A:ALA934 4.6 28.4 1.0
CB A:GLU937 4.6 34.8 1.0
CB A:ALA934 4.8 28.3 1.0
O A:HOH1251 4.9 36.7 1.0

Reference:

D.G.Thifault, P.Fromme, J.M.Martin-Garcia. Stapled Peptide Ligand Bound to the Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (Fak) To Be Published.
Page generated: Thu Aug 21 18:40:41 2025

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