Atomistry » Zinc » PDB 6o5h-6ogn » 6odz
Atomistry »
  Zinc »
    PDB 6o5h-6ogn »
      6odz »

Zinc in PDB 6odz: Benzensulfonamides Bearing Spyrohydantoin Moieties Act As Potent Inhibitors of Human Carbonic Anhydrases II and VII and Show Neuropathic Pain Attenuating Effects

Enzymatic activity of Benzensulfonamides Bearing Spyrohydantoin Moieties Act As Potent Inhibitors of Human Carbonic Anhydrases II and VII and Show Neuropathic Pain Attenuating Effects

All present enzymatic activity of Benzensulfonamides Bearing Spyrohydantoin Moieties Act As Potent Inhibitors of Human Carbonic Anhydrases II and VII and Show Neuropathic Pain Attenuating Effects:
4.2.1.1;

Protein crystallography data

The structure of Benzensulfonamides Bearing Spyrohydantoin Moieties Act As Potent Inhibitors of Human Carbonic Anhydrases II and VII and Show Neuropathic Pain Attenuating Effects, PDB code: 6odz was solved by T.S.Peat, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.97 / 1.30
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.289, 41.428, 72.223, 90.00, 104.39, 90.00
R / Rfree (%) 12 / 14.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Benzensulfonamides Bearing Spyrohydantoin Moieties Act As Potent Inhibitors of Human Carbonic Anhydrases II and VII and Show Neuropathic Pain Attenuating Effects (pdb code 6odz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Benzensulfonamides Bearing Spyrohydantoin Moieties Act As Potent Inhibitors of Human Carbonic Anhydrases II and VII and Show Neuropathic Pain Attenuating Effects, PDB code: 6odz:

Zinc binding site 1 out of 1 in 6odz

Go back to Zinc Binding Sites List in 6odz
Zinc binding site 1 out of 1 in the Benzensulfonamides Bearing Spyrohydantoin Moieties Act As Potent Inhibitors of Human Carbonic Anhydrases II and VII and Show Neuropathic Pain Attenuating Effects


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Benzensulfonamides Bearing Spyrohydantoin Moieties Act As Potent Inhibitors of Human Carbonic Anhydrases II and VII and Show Neuropathic Pain Attenuating Effects within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:2.7
occ:1.00
 N19 A:M8J302 1.9 3.5 1.0
NE2 A:HIS94 2.0 2.8 1.0
ND1 A:HIS119 2.0 2.5 1.0
NE2 A:HIS96 2.0 3.3 1.0
CE1 A:HIS119 2.9 2.3 1.0
CD2 A:HIS96 3.0 3.2 1.0
CD2 A:HIS94 3.0 2.9 1.0
CE1 A:HIS94 3.0 2.8 1.0
O20 A:M8J302 3.0 3.8 1.0
S17 A:M8J302 3.0 3.6 1.0
CE1 A:HIS96 3.1 3.6 1.0
CG A:HIS119 3.1 2.4 1.0
CB A:HIS119 3.6 2.5 1.0
O3 A:GOL304 3.7 9.3 0.5
OG1 A:THR199 3.9 3.1 1.0
OE1 A:GLU106 4.0 3.4 1.0
O18 A:M8J302 4.1 3.5 1.0
NE2 A:HIS119 4.1 2.5 1.0
ND1 A:HIS94 4.1 2.9 1.0
CG A:HIS94 4.2 2.9 1.0
ND1 A:HIS96 4.2 3.8 1.0
CG A:HIS96 4.2 3.4 1.0
C16 A:M8J302 4.2 5.2 1.0
CD2 A:HIS119 4.2 2.5 1.0
C3 A:GOL304 4.4 10.7 0.5
C3 A:GOL304 4.5 8.9 0.5
C2 A:GOL304 4.8 9.7 0.5
C21 A:M8J302 4.8 6.4 1.0
CD A:GLU106 4.9 3.3 1.0
C15 A:M8J302 5.0 6.2 1.0

Reference:

A.Angeli, L.Di Cesare Mannelli, C.Ghelardini, T.S.Peat, G.Bartolucci, M.Menicatti, F.Carta, C.T.Supuran. Benzensulfonamides Bearing Spyrohydantoin Moieties Act As Potent Inhibitors of Human Carbonic Anhydrases II and VII and Show Neuropathic Pain Attenuating Effects. Eur.J.Med.Chem. V. 177 188 2019.
ISSN: ISSN 0223-5234
PubMed: 31136893
DOI: 10.1016/J.EJMECH.2019.05.058
Page generated: Tue Oct 29 04:15:51 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy