Zinc in PDB 6lxe: Drosha-DGCR8 Complex

All present enzymatic activity of Drosha-DGCR8 Complex:
3.1.26.3;

The binding sites of Zinc atom in the Drosha-DGCR8 Complex (pdb code 6lxe). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Drosha-DGCR8 Complex, PDB code: 6lxe:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Drosha-DGCR8 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Drosha-DGCR8 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1401 b:0.7 occ:1.00 SG A:CYS676 2.0 0.0 1.0 NE2 A:HIS609 2.1 0.7 1.0 CE1 A:HIS680 2.2 0.0 1.0 NE2 A:HIS680 2.5 0.0 1.0 CE1 A:HIS609 2.5 0.7 1.0 SG A:CYS561 2.8 0.1 1.0 CD2 A:HIS609 3.3 0.7 1.0 O A:PRO677 3.4 0.0 1.0 ND1 A:HIS680 3.4 0.0 1.0 CB A:CYS676 3.6 0.0 1.0 ND1 A:HIS609 3.8 0.7 1.0 CD2 A:HIS680 3.8 0.0 1.0 CG A:HIS609 4.2 0.7 1.0 CG A:HIS680 4.3 0.0 1.0 CD2 A:LEU571 4.3 0.0 1.0 N A:PRO677 4.4 0.0 1.0 CD A:PRO677 4.5 0.0 1.0 C A:PRO677 4.5 0.0 1.0 C A:CYS676 4.6 0.0 1.0 N A:CYS561 4.6 0.1 1.0 CA A:CYS676 4.6 0.0 1.0 CB A:CYS561 4.6 0.1 1.0 CG A:PRO677 4.7 0.0 1.0 CG A:LEU571 4.9 0.0 1.0 CD1 A:LEU571 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Drosha-DGCR8 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Drosha-DGCR8 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1402 b:0.3 occ:1.00 SG A:CYS536 1.9 0.2 1.0 NE2 A:HIS1026 2.6 0.0 1.0 NE2 A:HIS549 2.7 0.0 1.0 CE1 A:HIS549 2.7 0.0 1.0 SG A:CYS538 2.8 0.2 1.0 CB A:CYS536 2.9 0.2 1.0 OH A:TYR1024 3.4 0.0 1.0 CE1 A:HIS1026 3.5 0.0 1.0 CD2 A:HIS1026 3.7 0.0 1.0 CA A:CYS536 3.8 0.2 1.0 NH2 A:ARG543 3.9 0.0 1.0 ND1 A:HIS549 4.0 0.0 1.0 CD2 A:HIS549 4.0 0.0 1.0 CB A:ALA542 4.2 0.0 1.0 CB A:CYS538 4.4 0.2 1.0 CZ A:TYR1024 4.4 0.0 1.0 C A:CYS536 4.5 0.2 1.0 CE2 A:TYR1024 4.6 0.0 1.0 O A:ALA542 4.6 0.0 1.0 ND1 A:HIS1026 4.6 0.0 1.0 CG A:HIS549 4.6 0.0 1.0 N A:CYS538 4.7 0.2 1.0 N A:LYS537 4.8 0.7 1.0 CG A:HIS1026 4.8 0.0 1.0 O A:SER539 4.8 0.6 1.0 N A:CYS536 5.0 0.2 1.0

W.Jin, J.Wang, C.P.Liu, H.W.Wang, R.M.Xu. Structural Basis For Pri-Mirna Recognition By Drosha. Mol.Cell 2020.
ISSN: ISSN 1097-2765
PubMed: 32220645
DOI: 10.1016/J.MOLCEL.2020.02.024