Zinc in PDB 6jed: Crystal Structure of Imp-1 Metallo-Beta-Lactamase in A Complex with Mcr

All present enzymatic activity of Crystal Structure of Imp-1 Metallo-Beta-Lactamase in A Complex with Mcr:
3.5.2.6;

The structure of Crystal Structure of Imp-1 Metallo-Beta-Lactamase in A Complex with Mcr, PDB code: 6jed was solved by J.Wachino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.53 / 1.57
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	35.920, 56.820, 101.060, 90.00, 90.00, 90.00
R / Rfree (%)	16.5 / 20

The binding sites of Zinc atom in the Crystal Structure of Imp-1 Metallo-Beta-Lactamase in A Complex with Mcr (pdb code 6jed). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Imp-1 Metallo-Beta-Lactamase in A Complex with Mcr, PDB code: 6jed:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Imp-1 Metallo-Beta-Lactamase in A Complex with Mcr


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Imp-1 Metallo-Beta-Lactamase in A Complex with Mcr within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:14.2 occ:1.00 NE2 A:HIS139 2.0 13.1 1.0 ND1 A:HIS79 2.0 13.0 1.0 NE2 A:HIS77 2.1 11.8 1.0 S2 A:MCR303 2.2 17.1 1.0 CD2 A:HIS77 3.0 13.1 1.0 CE1 A:HIS79 3.0 14.0 1.0 CD2 A:HIS139 3.0 12.5 1.0 CG A:HIS79 3.0 12.4 1.0 CE1 A:HIS139 3.1 13.4 1.0 CE1 A:HIS77 3.1 12.3 1.0 C2 A:MCR303 3.2 19.0 1.0 CB A:HIS79 3.4 11.9 1.0 ZN A:ZN302 3.6 15.8 0.8 C1 A:MCR303 3.8 19.0 1.0 O2 A:MCR303 3.8 17.5 1.0 OD1 A:ASP81 3.8 17.8 1.0 SG A:CYS158 3.9 15.7 1.0 CB A:CYS158 4.1 15.1 1.0 NE2 A:HIS79 4.2 15.5 1.0 CG A:HIS77 4.2 12.2 1.0 ND1 A:HIS139 4.2 14.4 1.0 CD2 A:HIS79 4.2 16.1 1.0 CG A:HIS139 4.2 12.8 1.0 ND1 A:HIS77 4.2 13.2 1.0 OD2 A:ASP81 4.5 16.5 1.0 O A:HOH554 4.5 38.4 1.0 CG A:ASP81 4.6 17.1 1.0 CG2 A:THR140 4.6 12.4 1.0 O1 A:MCR303 4.8 18.2 1.0 CA A:HIS79 4.8 12.4 1.0 O A:HOH580 4.9 27.8 1.0 O A:HOH558 4.9 26.8 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Imp-1 Metallo-Beta-Lactamase in A Complex with Mcr


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Imp-1 Metallo-Beta-Lactamase in A Complex with Mcr within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:15.8 occ:0.80 OD2 A:ASP81 2.0 16.5 1.0 NE2 A:HIS197 2.1 14.6 1.0 O2 A:MCR303 2.3 17.5 1.0 SG A:CYS158 2.3 15.7 1.0 S2 A:MCR303 2.4 17.1 1.0 C1 A:MCR303 3.0 19.0 1.0 CG A:ASP81 3.1 17.1 1.0 CD2 A:HIS197 3.1 16.7 1.0 C2 A:MCR303 3.1 19.0 1.0 CE1 A:HIS197 3.1 16.4 1.0 CB A:CYS158 3.4 15.1 1.0 OD1 A:ASP81 3.4 17.8 1.0 ZN A:ZN301 3.6 14.2 1.0 CE1 A:HIS77 4.2 12.3 1.0 CG A:HIS197 4.2 16.2 1.0 ND1 A:HIS197 4.2 17.4 1.0 NE2 A:HIS77 4.3 11.8 1.0 O1 A:MCR303 4.3 18.2 1.0 CB A:SER196 4.3 14.3 1.0 CB A:ASP81 4.4 13.7 1.0 NE2 A:HIS139 4.4 13.1 1.0 CA A:CYS158 4.6 15.4 1.0 OG A:SER196 4.7 14.9 1.0 CD A:LYS33 4.8 14.8 1.0 CE A:LYS33 4.8 14.4 1.0 O8 A:EPE304 4.8 43.6 0.8 CE1 A:HIS139 4.9 13.4 1.0

J.Wachino, J.Wachino. N/A N/A.