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Zinc in PDB 6hyg: Heteromeric Tandem IGG4/IGG1 Fc

Protein crystallography data

The structure of Heteromeric Tandem IGG4/IGG1 Fc, PDB code: 6hyg was solved by J.B.Casaletto, M.L.Geddie, A.O.Abu-Yousif, K.Masson, A.Fulgham, A.Boudot, T.Maiwald, J.D.Kearns, N.Kohli, S.Su, M.Razlog, A.Raue, A.Kalra, M.Hakansson, D.T.Logan, M.Welin, S.Chattopadhyay, B.D.Harms, U.B.Nielsen, B.Schoeberl, A.A.Lugovskoy, G.Macbeath, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.28 / 2.31
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 136.119, 63.253, 77.551, 90.00, 90.00, 90.00
R / Rfree (%) 25.8 / 27.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Heteromeric Tandem IGG4/IGG1 Fc (pdb code 6hyg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Heteromeric Tandem IGG4/IGG1 Fc, PDB code: 6hyg:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 6hyg

Go back to Zinc Binding Sites List in 6hyg
Zinc binding site 1 out of 2 in the Heteromeric Tandem IGG4/IGG1 Fc


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Heteromeric Tandem IGG4/IGG1 Fc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:40.8
occ:1.00
NE2 A:HIS90 1.9 36.1 1.0
NE2 A:HIS215 2.1 46.7 1.0
CE1 A:HIS90 2.7 38.3 1.0
CE1 A:HIS215 3.1 41.6 1.0
CD2 A:HIS215 3.1 41.2 1.0
CD2 A:HIS90 3.1 40.1 1.0
ND1 A:HIS90 3.9 37.4 1.0
CD1 A:LEU94 4.0 43.4 1.0
CG A:HIS90 4.1 39.2 1.0
ND1 A:HIS215 4.1 42.4 1.0
CG A:HIS215 4.2 39.2 1.0

Zinc binding site 2 out of 2 in 6hyg

Go back to Zinc Binding Sites List in 6hyg
Zinc binding site 2 out of 2 in the Heteromeric Tandem IGG4/IGG1 Fc


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Heteromeric Tandem IGG4/IGG1 Fc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn502

b:40.0
occ:1.00
NE2 A:HIS355 2.0 35.0 1.0
O A:HOH678 2.1 28.9 1.0
NE2 A:HIS480 2.1 43.0 1.0
CE1 A:HIS355 2.9 37.0 1.0
CD2 A:HIS355 3.1 38.5 1.0
CD2 A:HIS480 3.1 40.8 1.0
CE1 A:HIS480 3.1 40.6 1.0
CD1 A:LEU359 4.0 40.5 1.0
ND1 A:HIS355 4.1 36.3 1.0
CG A:HIS355 4.2 38.7 1.0
ND1 A:HIS480 4.3 40.6 1.0
CG A:HIS480 4.3 39.1 1.0

Reference:

J.B.Casaletto, M.L.Geddie, A.O.Abu-Yousif, K.Masson, A.Fulgham, A.Boudot, T.Maiwald, J.D.Kearns, N.Kohli, S.Su, M.Razlog, A.Raue, A.Kalra, M.Hakansson, D.T.Logan, M.Welin, S.Chattopadhyay, B.D.Harms, U.B.Nielsen, B.Schoeberl, A.A.Lugovskoy, G.Macbeath. Mm-131, A Bispecific Anti-Met/Epcam Mab, Inhibits Hgf-Dependent and Hgf-Independent Met Signaling Through Concurrent Binding to Epcam. Proc.Natl.Acad.Sci.Usa V. 116 7533 2019.
ISSN: ESSN 1091-6490
PubMed: 30898885
DOI: 10.1073/PNAS.1819085116
Page generated: Mon Oct 28 23:26:46 2024

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