Zinc in PDB 6ha6: Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPV3 (220- 246)

All present enzymatic activity of Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPV3 (220- 246):
1.14.11.30;

The structure of Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPV3 (220- 246), PDB code: 6ha6 was solved by T.M.Leissing, I.J.Clifton, B.G.Saward, X.Lu, R.J.Hopkinson, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	61.58 / 1.98
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	87.080, 87.080, 149.360, 90.00, 90.00, 90.00
R / Rfree (%)	18.1 / 20.3

The binding sites of Zinc atom in the Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPV3 (220- 246) (pdb code 6ha6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPV3 (220- 246), PDB code: 6ha6:

Zinc binding site 1 out of 1 in the Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPV3 (220- 246)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPV3 (220- 246) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn409 b:46.4 occ:1.00 OD2 A:ASP201 2.1 41.5 1.0 O2' A:OGA401 2.1 54.0 1.0 O A:HOH552 2.1 62.3 1.0 NE2 A:HIS199 2.1 54.9 1.0 NE2 A:HIS279 2.1 54.0 1.0 O2 A:OGA401 2.2 50.4 1.0 C2 A:OGA401 2.8 50.0 1.0 C1 A:OGA401 2.9 48.4 1.0 CE1 A:HIS199 3.0 47.5 1.0 CD2 A:HIS279 3.1 46.3 1.0 CG A:ASP201 3.1 46.1 1.0 CD2 A:HIS199 3.1 46.7 1.0 CE1 A:HIS279 3.1 47.1 1.0 OD1 A:ASP201 3.4 44.5 1.0 O A:HOH571 3.9 43.8 1.0 O1 A:OGA401 4.1 52.5 1.0 N1 A:OGA401 4.1 50.0 1.0 ND1 A:HIS199 4.1 51.0 1.0 CG A:HIS279 4.2 50.1 1.0 CG A:HIS199 4.2 47.7 1.0 ND1 A:HIS279 4.2 50.2 1.0 CB A:ASP201 4.4 44.5 1.0 CZ2 A:TRP296 4.4 58.4 1.0 C4 A:OGA401 4.9 54.0 1.0 CG D:ASN242 5.0 90.4 1.0

T.M.Leissing, I.J.Clifton, B.G.Saward, X.Lu, R.J.Hopkinson, C.J.Schofield. Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPV3 (220-246) To Be Published.