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Zinc in PDB 6fe0: Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide.
Enzymatic activity of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide.
All present enzymatic activity of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide.:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide., PDB code: 6fe0
was solved by
J.Leitans,
K.Tars,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 26.00 / 1.91 |
| Space group | H 3 |
| Cell size a, b, c (Å), α, β, γ (°) | 152.859, 152.859, 171.469, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 16.8 / 20.4 |
Other elements in 6fe0:
The structure of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide. also contains other interesting chemical elements:
| Fluorine | (F) | 12 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide.
(pdb code 6fe0). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide., PDB code: 6fe0:
Jump to Zinc binding site number: 1; 2; 3; 4;
In total 4 binding sites of Zinc where determined in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide., PDB code: 6fe0:
Jump to Zinc binding site number: 1; 2; 3; 4;
Zinc binding site 1 out of 4 in 6fe0
Go back to
Zinc Binding Sites List in 6fe0
Zinc binding site 1 out
of 4 in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide. within 5.0Å range:
|
Zinc binding site 2 out of 4 in 6fe0
Go back to
Zinc Binding Sites List in 6fe0
Zinc binding site 2 out
of 4 in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide. within 5.0Å range:
|
Zinc binding site 3 out of 4 in 6fe0
Go back to
Zinc Binding Sites List in 6fe0
Zinc binding site 3 out
of 4 in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide. within 5.0Å range:
|
Zinc binding site 4 out of 4 in 6fe0
Go back to
Zinc Binding Sites List in 6fe0
Zinc binding site 4 out
of 4 in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with Benzenesulfonamide. within 5.0Å range:
|
Reference:
J.Kazokaite,
R.Niemans,
V.Dudutiene,
H.M.Becker,
J.Leitans,
A.Zubriene,
L.Baranauskiene,
G.Gondi,
R.Zeidler,
J.Matuliene,
K.Tars,
A.Yaromina,
P.Lambin,
L.J.Dubois,
D.Matulis.
Novel Fluorinated Carbonic Anhydrase IX Inhibitors Reduce Hypoxia-Induced Acidification and Clonogenic Survival of Cancer Cells. Oncotarget V. 9 26800 2018.
ISSN: ESSN 1949-2553
PubMed: 29928486
DOI: 10.18632/ONCOTARGET.25508
Page generated: Mon Oct 28 20:52:39 2024
ISSN: ESSN 1949-2553
PubMed: 29928486
DOI: 10.18632/ONCOTARGET.25508
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