Zinc in PDB 6fbr: Crystal Structure of the Human Retinoid X Receptor Dna-Binding Domain Bound to the Human Mep DR1 Response Element, pH 4.2

The structure of Crystal Structure of the Human Retinoid X Receptor Dna-Binding Domain Bound to the Human Mep DR1 Response Element, pH 4.2, PDB code: 6fbr was solved by A.G.Mcewen, P.Poussin-Courmontagne, J.Osz, N.Rochel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.29 / 2.10
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	55.659, 55.659, 166.131, 90.00, 90.00, 120.00
R / Rfree (%)	17.8 / 23.2

The binding sites of Zinc atom in the Crystal Structure of the Human Retinoid X Receptor Dna-Binding Domain Bound to the Human Mep DR1 Response Element, pH 4.2 (pdb code 6fbr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Human Retinoid X Receptor Dna-Binding Domain Bound to the Human Mep DR1 Response Element, pH 4.2, PDB code: 6fbr:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of the Human Retinoid X Receptor Dna-Binding Domain Bound to the Human Mep DR1 Response Element, pH 4.2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Human Retinoid X Receptor Dna-Binding Domain Bound to the Human Mep DR1 Response Element, pH 4.2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:54.0 occ:1.00 SG A:CYS152 2.3 40.8 1.0 SG A:CYS155 2.3 45.7 1.0 SG A:CYS135 2.4 44.7 1.0 SG A:CYS138 2.4 42.9 1.0 CB A:CYS135 3.3 41.8 1.0 CB A:CYS155 3.3 40.7 1.0 CB A:CYS138 3.4 40.3 1.0 CB A:CYS152 3.5 37.8 1.0 N A:CYS138 3.8 41.8 1.0 N A:CYS152 3.9 37.8 1.0 N A:CYS155 4.1 39.9 1.0 NH1 A:ARG184 4.2 42.5 1.0 CA A:CYS138 4.2 41.7 1.0 CA A:CYS152 4.3 37.9 1.0 CA A:CYS155 4.3 39.8 1.0 CB A:ILE137 4.4 45.0 1.0 CB A:ASP140 4.4 35.8 1.0 NH2 A:ARG191 4.7 32.7 1.0 CA A:CYS135 4.7 43.8 1.0 C A:CYS138 4.8 45.0 1.0 C A:ILE137 4.8 45.7 1.0 N A:ASP140 4.9 37.3 1.0 N A:GLY139 4.9 40.5 1.0 C A:CYS152 4.9 41.6 1.0 CD A:ARG184 4.9 42.5 1.0 CA A:ILE137 5.0 43.3 1.0 O A:CYS152 5.0 40.1 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of the Human Retinoid X Receptor Dna-Binding Domain Bound to the Human Mep DR1 Response Element, pH 4.2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Human Retinoid X Receptor Dna-Binding Domain Bound to the Human Mep DR1 Response Element, pH 4.2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn301 b:56.0 occ:1.00 SG B:CYS138 2.3 47.1 1.0 SG B:CYS135 2.3 43.0 1.0 SG B:CYS155 2.4 44.4 1.0 SG B:CYS152 2.4 45.5 1.0 CB B:CYS135 3.2 39.6 1.0 CB B:CYS155 3.3 39.3 1.0 CB B:CYS138 3.4 44.0 1.0 CB B:CYS152 3.6 41.8 1.0 N B:CYS138 3.7 45.0 1.0 N B:CYS152 3.9 41.2 1.0 CA B:CYS138 4.1 44.9 1.0 N B:CYS155 4.1 39.9 1.0 CB B:ILE137 4.3 47.7 1.0 CA B:CYS155 4.3 39.4 1.0 CA B:CYS152 4.3 40.8 1.0 NH1 B:ARG184 4.5 46.7 1.0 CB B:ASP140 4.5 45.0 1.0 CA B:CYS135 4.6 41.0 1.0 C B:ILE137 4.7 50.1 1.0 C B:CYS138 4.8 51.5 1.0 NH2 B:ARG191 4.9 42.8 1.0 N B:GLY139 4.9 48.4 1.0 N B:ASP140 4.9 44.7 1.0 CD B:ARG184 4.9 48.1 1.0 CA B:ILE137 4.9 45.1 1.0 CG1 B:ILE137 4.9 48.9 1.0

J.Osz, A.G.Mcewen, J.Wolf, P.Poussin-Courmontagne, C.Peluso-Iltis, Y.Chebaro, B.Kieffer, N.Rochel. Modulation of Rxr-Dna Complex Assembly By Dna Context. Mol. Cell. Endocrinol. V. 481 44 2019.
ISSN: ISSN 1872-8057
PubMed: 30476562
DOI: 10.1016/J.MCE.2018.11.008