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Zinc in PDB 6bv2: Crystal Structure of Porcine Aminopeptidase-N with Isoleucine

Enzymatic activity of Crystal Structure of Porcine Aminopeptidase-N with Isoleucine

All present enzymatic activity of Crystal Structure of Porcine Aminopeptidase-N with Isoleucine:
3.4.11.2;

Protein crystallography data

The structure of Crystal Structure of Porcine Aminopeptidase-N with Isoleucine, PDB code: 6bv2 was solved by L.Chen, Y.-L.Lin, F.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.14
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 260.359, 62.923, 81.733, 90.00, 100.51, 90.00
R / Rfree (%) 21.3 / 25.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Porcine Aminopeptidase-N with Isoleucine (pdb code 6bv2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Porcine Aminopeptidase-N with Isoleucine, PDB code: 6bv2:

Zinc binding site 1 out of 1 in 6bv2

Go back to Zinc Binding Sites List in 6bv2
Zinc binding site 1 out of 1 in the Crystal Structure of Porcine Aminopeptidase-N with Isoleucine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Porcine Aminopeptidase-N with Isoleucine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1035

b:30.3
occ:1.00
OE2 A:GLU406 1.8 31.7 1.0
NE2 A:HIS383 2.0 31.9 1.0
NE2 A:HIS387 2.0 32.0 1.0
O A:HOH1292 2.2 34.3 1.0
CD A:GLU406 2.8 32.2 1.0
CD2 A:HIS387 2.9 32.0 1.0
CD2 A:HIS383 2.9 30.7 1.0
CE1 A:HIS383 3.0 32.3 1.0
OE1 A:GLU406 3.0 29.8 1.0
CE1 A:HIS387 3.1 29.8 1.0
OXT A:ILE1024 3.4 38.1 1.0
C A:ILE1024 3.9 40.7 1.0
N A:ILE1024 4.0 36.0 1.0
CG A:HIS387 4.1 31.8 1.0
CB A:ALA409 4.1 32.4 1.0
ND1 A:HIS383 4.1 30.0 1.0
CG A:HIS383 4.1 33.0 1.0
ND1 A:HIS387 4.1 31.7 1.0
OE1 A:GLU350 4.1 27.9 1.0
CG A:GLU406 4.2 31.5 1.0
OE2 A:GLU384 4.4 32.5 1.0
CA A:ILE1024 4.4 38.4 1.0
CE2 A:TYR472 4.5 33.8 1.0
O A:ILE1024 4.5 44.9 1.0
CA A:GLU406 4.5 32.5 1.0
CD A:GLU350 4.6 31.0 1.0
CB A:GLU406 4.6 31.4 1.0
OE1 A:GLU384 4.7 30.9 1.0
OE2 A:GLU350 4.9 27.9 1.0
CD A:GLU384 4.9 30.8 1.0
OH A:TYR472 5.0 30.5 1.0

Reference:

S.Joshi, L.Chen, M.B.Winter, Y.L.Lin, Y.Yang, M.Shapovalova, P.M.Smith, C.Liu, F.Li, A.M.Lebeau. The Rational Design of Therapeutic Peptides For Aminopeptidase N Using A Substrate-Based Approach. Sci Rep V. 7 1424 2017.
ISSN: ESSN 2045-2322
PubMed: 28465619
DOI: 10.1038/S41598-017-01542-5
Page generated: Thu Aug 21 12:51:10 2025

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