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Atomistry » Zinc » PDB 6a57-6agg » 6acb » |
Zinc in PDB 6acb: Crystal Structure of PDE5 in Complex with Inhibitor LW1805Enzymatic activity of Crystal Structure of PDE5 in Complex with Inhibitor LW1805
All present enzymatic activity of Crystal Structure of PDE5 in Complex with Inhibitor LW1805:
3.1.4.35; Protein crystallography data
The structure of Crystal Structure of PDE5 in Complex with Inhibitor LW1805, PDB code: 6acb
was solved by
D.Wu,
Y.D.Huang,
Y.Y.Huang,
H.B.Luo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6acb:
The structure of Crystal Structure of PDE5 in Complex with Inhibitor LW1805 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of PDE5 in Complex with Inhibitor LW1805
(pdb code 6acb). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of PDE5 in Complex with Inhibitor LW1805, PDB code: 6acb: Zinc binding site 1 out of 1 in 6acbGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Crystal Structure of PDE5 in Complex with Inhibitor LW1805
![]() Mono view ![]() Stereo pair view
Reference:
D.Wu,
Y.Huang,
Y.Chen,
Y.Y.Huang,
H.Geng,
T.Zhang,
C.Zhang,
Z.Li,
L.Guo,
J.Chen,
H.B.Luo.
Optimization of Chromeno[2,3- C]Pyrrol-9(2 H)-Ones As Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-Ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. J. Med. Chem. V. 61 8468 2018.
Page generated: Mon Oct 28 17:27:29 2024
ISSN: ISSN 1520-4804 PubMed: 30148362 DOI: 10.1021/ACS.JMEDCHEM.8B01209 |
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