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Atomistry » Zinc » PDB 6a57-6agg » 6a84 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 6a57-6agg » 6a84 » |
Zinc in PDB 6a84: Tankyrase-2 in Complex with Compound 15DEnzymatic activity of Tankyrase-2 in Complex with Compound 15D
All present enzymatic activity of Tankyrase-2 in Complex with Compound 15D:
2.4.2.30; Protein crystallography data
The structure of Tankyrase-2 in Complex with Compound 15D, PDB code: 6a84
was solved by
H.Niwa,
F.Shirai,
S.Sato,
N.Yoshimoto,
T.Tsumura,
M.Okue,
M.Shirouzu,
H.Seimiya,
T.Umehara,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6a84:
The structure of Tankyrase-2 in Complex with Compound 15D also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Tankyrase-2 in Complex with Compound 15D
(pdb code 6a84). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Tankyrase-2 in Complex with Compound 15D, PDB code: 6a84: Zinc binding site 1 out of 1 in 6a84Go back to![]() ![]()
Zinc binding site 1 out
of 1 in the Tankyrase-2 in Complex with Compound 15D
![]() Mono view ![]() Stereo pair view
Reference:
F.Shirai,
T.Tsumura,
Y.Yashiroda,
H.Yuki,
H.Niwa,
S.Sato,
T.Chikada,
Y.Koda,
K.Washizuka,
N.Yoshimoto,
M.Abe,
T.Onuki,
Y.Mazaki,
C.Hirama,
T.Fukami,
H.Watanabe,
T.Honma,
T.Umehara,
M.Shirouzu,
M.Okue,
Y.Kano,
T.Watanabe,
K.Kitamura,
E.Shitara,
Y.Muramatsu,
H.Yoshida,
A.Mizutani,
H.Seimiya,
M.Yoshida,
H.Koyama.
Discovery of Novel Spiroindoline Derivatives As Selective Tankyrase Inhibitors. J. Med. Chem. V. 62 3407 2019.
Page generated: Mon Oct 28 17:25:34 2024
ISSN: ISSN 1520-4804 PubMed: 30883102 DOI: 10.1021/ACS.JMEDCHEM.8B01888 |
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