Atomistry » Zinc » PDB 5w9s-5wgv » 5wbv
Atomistry »
  Zinc »
    PDB 5w9s-5wgv »
      5wbv »

Zinc in PDB 5wbv: Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor

Enzymatic activity of Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor

All present enzymatic activity of Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor:
2.1.1.43;

Protein crystallography data

The structure of Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor, PDB code: 5wbv was solved by L.Halabelian, W.Tempel, P.J.Brown, C.Bountra, A.M.Edwards, C.H.Arrowsmith, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.00 / 2.30
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 46.324, 50.559, 74.818, 101.26, 107.51, 89.67
R / Rfree (%) 23.4 / 26.9

Other elements in 5wbv:

The structure of Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor (pdb code 5wbv). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor, PDB code: 5wbv:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5wbv

Go back to Zinc Binding Sites List in 5wbv
Zinc binding site 1 out of 2 in the Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:56.8
occ:1.00
SG A:CYS275 2.3 57.1 1.0
SG A:CYS321 2.4 54.5 1.0
SG A:CYS324 2.5 60.4 1.0
SG A:CYS319 2.5 53.1 1.0
CB A:CYS275 3.4 53.3 1.0
CB A:CYS324 3.5 57.7 1.0
CB A:CYS319 3.6 50.1 1.0
CB A:CYS321 3.6 49.5 1.0
N A:CYS275 3.9 48.9 1.0
N A:CYS324 4.1 59.8 1.0
N A:CYS321 4.2 49.9 1.0
CA A:CYS275 4.2 50.6 1.0
NE2 A:HIS273 4.2 46.3 1.0
CA A:CYS324 4.3 59.9 1.0
CA A:CYS321 4.4 50.7 1.0
CD2 A:HIS273 4.4 45.5 1.0
CA A:CYS319 4.8 49.7 1.0
C A:CYS319 4.8 52.6 1.0
C A:ASP274 4.9 50.2 1.0
C A:CYS321 4.9 60.6 1.0
O A:CYS321 4.9 60.6 1.0

Zinc binding site 2 out of 2 in 5wbv

Go back to Zinc Binding Sites List in 5wbv
Zinc binding site 2 out of 2 in the Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn401

b:66.3
occ:1.00
SG B:CYS275 2.3 64.7 1.0
SG B:CYS319 2.3 58.8 1.0
SG B:CYS321 2.4 59.5 1.0
SG B:CYS324 2.5 75.3 1.0
CB B:CYS319 3.3 56.5 1.0
CB B:CYS275 3.4 61.7 1.0
CB B:CYS324 3.6 72.6 1.0
CB B:CYS321 3.7 52.7 1.0
N B:CYS275 4.0 53.8 1.0
NE2 B:HIS273 4.2 55.2 1.0
N B:CYS324 4.2 73.1 1.0
N B:CYS321 4.2 52.9 1.0
CA B:CYS275 4.3 57.5 1.0
CD2 B:HIS273 4.3 53.8 1.0
CA B:CYS324 4.4 75.3 1.0
CA B:CYS321 4.4 53.6 1.0
CA B:CYS319 4.6 55.8 1.0
C B:CYS319 4.7 60.6 1.0
C B:ASP274 4.9 51.6 1.0
C B:CYS321 5.0 63.9 1.0
O B:CYS321 5.0 64.3 1.0

Reference:

L.Halabelian, W.Tempel, P.J.Brown, C.Bountra, A.M.Edwards, C.H.Arrowsmith, Structural Genomics Consortium (Sgc). Crystal Structure of the Set Domain of Human SUV420H1 in Complex with Inhibitor To Be Published.
Page generated: Mon Oct 28 14:03:25 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy