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Zinc in PDB 5w0g: Structure of U2AF65 (U2AF2) RRM1 at 1.07 Resolution

Protein crystallography data

The structure of Structure of U2AF65 (U2AF2) RRM1 at 1.07 Resolution, PDB code: 5w0g was solved by A.A.Agrawal, J.L.Jenkins, C.L.Kielkopf, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 16.98 / 1.07
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 28.707, 28.707, 185.851, 90.00, 90.00, 90.00
R / Rfree (%) 13.5 / 15.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of U2AF65 (U2AF2) RRM1 at 1.07 Resolution (pdb code 5w0g). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of U2AF65 (U2AF2) RRM1 at 1.07 Resolution, PDB code: 5w0g:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5w0g

Go back to Zinc Binding Sites List in 5w0g
Zinc binding site 1 out of 2 in the Structure of U2AF65 (U2AF2) RRM1 at 1.07 Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of U2AF65 (U2AF2) RRM1 at 1.07 Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:25.0
occ:0.50
O A:HOH401 1.9 29.5 1.0
O A:HOH493 2.0 16.6 1.0
OE1 A:GLU162 2.0 32.3 1.0
O A:HOH407 2.4 41.6 1.0
CD A:GLU162 3.2 33.4 1.0
O A:HOH459 3.7 24.7 1.0
OE2 A:GLU162 3.7 34.7 1.0
O A:VAL189 4.2 19.8 1.0
HB2 A:GLU162 4.3 24.8 1.0
CG A:GLU162 4.4 26.4 1.0
OE1 A:GLN190 4.5 57.0 1.0
HB3 A:GLU162 4.5 24.8 1.0
CB A:GLU162 4.6 20.6 1.0
HG3 A:GLU162 5.0 31.7 1.0
HG2 A:GLU162 5.0 31.7 1.0

Zinc binding site 2 out of 2 in 5w0g

Go back to Zinc Binding Sites List in 5w0g
Zinc binding site 2 out of 2 in the Structure of U2AF65 (U2AF2) RRM1 at 1.07 Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of U2AF65 (U2AF2) RRM1 at 1.07 Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn302

b:17.9
occ:1.00
O A:HOH405 1.8 36.5 1.0
OD2 A:ASP167 1.9 15.9 1.0
OE2 A:GLU163 1.9 20.3 1.0
O A:HOH476 2.0 26.7 1.0
CG A:ASP167 2.7 14.2 1.0
O A:HOH485 2.8 37.1 0.5
OD1 A:ASP167 2.8 16.5 1.0
CD A:GLU163 2.9 18.8 1.0
HG3 A:GLU163 2.9 21.2 1.0
CG A:GLU163 3.2 17.6 1.0
HG2 A:GLU163 3.3 21.2 1.0
O A:HOH485 4.0 38.8 0.5
O A:HOH490 4.0 42.0 1.0
O A:HOH432 4.0 40.1 1.0
OE1 A:GLU163 4.0 23.9 1.0
O A:HOH408 4.0 11.6 0.5
CB A:ASP167 4.2 12.9 1.0
O A:HOH408 4.4 25.4 0.5
HB3 A:ASP167 4.4 15.5 1.0
O A:HOH491 4.4 29.4 0.6
HB2 A:ASP167 4.5 15.5 1.0
O A:GLU163 4.7 13.2 1.0
CB A:GLU163 4.7 15.7 1.0
O A:HOH491 4.9 15.2 0.4

Reference:

E.Glasser, A.A.Agrawal, J.L.Jenkins, C.L.Kielkopf. Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 Rna Recognition Motifs. Biochemistry V. 56 4757 2017.
ISSN: ISSN 1520-4995
PubMed: 28850223
DOI: 10.1021/ACS.BIOCHEM.7B00551
Page generated: Mon Oct 28 13:34:44 2024

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