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Atomistry » Zinc » PDB 5um3-5uqp » 5uoy | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 5um3-5uqp » 5uoy » |
Zinc in PDB 5uoy: Crystal Structure of Human PDE1B Catalytic Domain in Complex with Inhibitor 16J (6-(4-Methoxybenzyl)-9-((Tetrahydro-2H-Pyran-4-Yl) Methyl)-8,9,10,11-Tetrahydropyrido[4',3':4,5]Thieno[3,2-E][1,2, 4]Triazolo[1,5-C]Pyrimidin-5(6H)-One)Enzymatic activity of Crystal Structure of Human PDE1B Catalytic Domain in Complex with Inhibitor 16J (6-(4-Methoxybenzyl)-9-((Tetrahydro-2H-Pyran-4-Yl) Methyl)-8,9,10,11-Tetrahydropyrido[4',3':4,5]Thieno[3,2-E][1,2, 4]Triazolo[1,5-C]Pyrimidin-5(6H)-One)
All present enzymatic activity of Crystal Structure of Human PDE1B Catalytic Domain in Complex with Inhibitor 16J (6-(4-Methoxybenzyl)-9-((Tetrahydro-2H-Pyran-4-Yl) Methyl)-8,9,10,11-Tetrahydropyrido[4',3':4,5]Thieno[3,2-E][1,2, 4]Triazolo[1,5-C]Pyrimidin-5(6H)-One):
3.1.4.17; Protein crystallography data
The structure of Crystal Structure of Human PDE1B Catalytic Domain in Complex with Inhibitor 16J (6-(4-Methoxybenzyl)-9-((Tetrahydro-2H-Pyran-4-Yl) Methyl)-8,9,10,11-Tetrahydropyrido[4',3':4,5]Thieno[3,2-E][1,2, 4]Triazolo[1,5-C]Pyrimidin-5(6H)-One), PDB code: 5uoy
was solved by
E.P.Cedervall,
C.K.Allerston,
R.Xu,
V.Sridhar,
R.Barker,
K.Aertgeerts,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5uoy:
The structure of Crystal Structure of Human PDE1B Catalytic Domain in Complex with Inhibitor 16J (6-(4-Methoxybenzyl)-9-((Tetrahydro-2H-Pyran-4-Yl) Methyl)-8,9,10,11-Tetrahydropyrido[4',3':4,5]Thieno[3,2-E][1,2, 4]Triazolo[1,5-C]Pyrimidin-5(6H)-One) also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human PDE1B Catalytic Domain in Complex with Inhibitor 16J (6-(4-Methoxybenzyl)-9-((Tetrahydro-2H-Pyran-4-Yl) Methyl)-8,9,10,11-Tetrahydropyrido[4',3':4,5]Thieno[3,2-E][1,2, 4]Triazolo[1,5-C]Pyrimidin-5(6H)-One)
(pdb code 5uoy). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human PDE1B Catalytic Domain in Complex with Inhibitor 16J (6-(4-Methoxybenzyl)-9-((Tetrahydro-2H-Pyran-4-Yl) Methyl)-8,9,10,11-Tetrahydropyrido[4',3':4,5]Thieno[3,2-E][1,2, 4]Triazolo[1,5-C]Pyrimidin-5(6H)-One), PDB code: 5uoy: Zinc binding site 1 out of 1 in 5uoyGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Crystal Structure of Human PDE1B Catalytic Domain in Complex with Inhibitor 16J (6-(4-Methoxybenzyl)-9-((Tetrahydro-2H-Pyran-4-Yl) Methyl)-8,9,10,11-Tetrahydropyrido[4',3':4,5]Thieno[3,2-E][1,2, 4]Triazolo[1,5-C]Pyrimidin-5(6H)-One)
![]() Mono view ![]() Stereo pair view
Reference:
B.Dyck,
B.Branstetter,
T.Gharbaoui,
A.R.Hudson,
J.G.Breitenbucher,
L.Gomez,
I.Botrous,
T.Marrone,
R.Barido,
C.K.Allerston,
E.P.Cedervall,
R.Xu,
V.Sridhar,
R.Barker,
K.Aertgeerts,
K.Schmelzer,
D.Neul,
D.Lee,
M.E.Massari,
C.B.Andersen,
K.Sebring,
X.Zhou,
R.Petroski,
J.Limberis,
M.Augustin,
L.E.Chun,
T.E.Edwards,
M.Peters,
A.Tabatabaei.
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties. J. Med. Chem. V. 60 3472 2017.
Page generated: Mon Oct 28 11:24:27 2024
ISSN: ISSN 1520-4804 PubMed: 28406621 DOI: 10.1021/ACS.JMEDCHEM.7B00302 |
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