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Zinc in PDB 5tmn: Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues

Enzymatic activity of Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues

All present enzymatic activity of Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues:
3.4.24.27;

Protein crystallography data

The structure of Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues, PDB code: 5tmn was solved by H.M.Holden, D.E.Tronrud, A.F.Monzingo, L.H.Weaver, B.W.Matthews, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 1.60
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 94.100, 94.100, 131.400, 90.00, 90.00, 120.00
R / Rfree (%) n/a / n/a

Other elements in 5tmn:

The structure of Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues also contains other interesting chemical elements:

Calcium (Ca) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues (pdb code 5tmn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues, PDB code: 5tmn:

Zinc binding site 1 out of 1 in 5tmn

Go back to Zinc Binding Sites List in 5tmn
Zinc binding site 1 out of 1 in the Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn322

b:9.5
occ:1.00
 NE2 E:HIS142 2.0 12.1 1.0
OE1 E:GLU166 2.1 11.2 1.0
O21 E:0PJ317 2.1 9.8 1.0
NE2 E:HIS146 2.1 9.3 1.0
CD E:GLU166 2.8 9.2 1.0
OE2 E:GLU166 2.9 11.2 1.0
CE1 E:HIS146 2.9 8.3 1.0
O11 E:0PJ317 3.0 10.6 1.0
CE1 E:HIS142 3.0 7.7 1.0
P E:0PJ317 3.1 9.7 1.0
CD2 E:HIS142 3.1 8.3 1.0
CD2 E:HIS146 3.2 10.6 1.0
OH E:TYR157 3.8 10.9 1.0
N1 E:0PJ317 4.0 2.6 1.0
NE2 E:HIS231 4.1 7.5 1.0
ND1 E:HIS146 4.1 10.2 1.0
ND1 E:HIS142 4.2 6.2 1.0
CG E:HIS142 4.2 8.2 1.0
CA E:0PJ317 4.2 13.4 1.0
CG E:GLU166 4.3 6.1 1.0
CG E:HIS146 4.3 8.4 1.0
CB E:SER169 4.5 3.7 1.0
C E:0PJ317 4.5 3.8 1.0
N E:0PJ317 4.6 10.7 1.0
CD2 E:HIS231 4.6 10.9 1.0
C9 E:0PJ317 4.6 19.8 1.0
O E:0PJ317 4.7 9.2 1.0
O E:HOH492 4.8 9.6 1.0
OG E:SER169 4.8 8.8 1.0
CZ E:TYR157 4.8 11.9 1.0
OE1 E:GLU143 4.9 10.8 1.0
CA E:GLU166 4.9 6.4 1.0
CE2 E:TYR157 4.9 16.7 1.0

Reference:

H.M.Holden, D.E.Tronrud, A.F.Monzingo, L.H.Weaver, B.W.Matthews. Slow- and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding: Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues. Biochemistry V. 26 8542 1987.
ISSN: ISSN 0006-2960
PubMed: 3442675
DOI: 10.1021/BI00400A008
Page generated: Mon Oct 28 08:40:19 2024

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