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Zinc in PDB 5ogo: Crystal Structure of Chimeric Carbonic Anhydrase I with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide

Enzymatic activity of Crystal Structure of Chimeric Carbonic Anhydrase I with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide

All present enzymatic activity of Crystal Structure of Chimeric Carbonic Anhydrase I with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide:
4.2.1.1;

Protein crystallography data

The structure of Crystal Structure of Chimeric Carbonic Anhydrase I with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide, PDB code: 5ogo was solved by A.Smirnov, E.Manakova, S.Grazulis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.72 / 0.99
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.094, 41.426, 71.654, 90.00, 104.35, 90.00
R / Rfree (%) 12.4 / 14.8

Other elements in 5ogo:

The structure of Crystal Structure of Chimeric Carbonic Anhydrase I with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide also contains other interesting chemical elements:

Fluorine (F) 9 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Chimeric Carbonic Anhydrase I with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide (pdb code 5ogo). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Chimeric Carbonic Anhydrase I with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide, PDB code: 5ogo:

Zinc binding site 1 out of 1 in 5ogo

Go back to Zinc Binding Sites List in 5ogo
Zinc binding site 1 out of 1 in the Crystal Structure of Chimeric Carbonic Anhydrase I with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Chimeric Carbonic Anhydrase I with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:5.1
occ:1.00
 N10 A:WWO302 1.9 5.7 1.0
NE2 A:HIS94 2.0 5.5 1.0
ND1 A:HIS119 2.0 5.1 1.0
NE2 A:HIS96 2.0 5.6 1.0
CE1 A:HIS119 2.9 5.1 1.0
CD2 A:HIS96 3.0 5.7 1.0
CD2 A:HIS94 3.0 5.9 1.0
CE1 A:HIS94 3.0 5.8 1.0
CE1 A:HIS96 3.0 6.6 1.0
S7 A:WWO302 3.1 5.7 1.0
O9 A:WWO302 3.1 6.1 1.0
CG A:HIS119 3.1 5.1 1.0
CB A:HIS119 3.6 5.4 1.0
OE1 A:GLU106 3.9 5.8 1.0
OG1 A:THR199 4.0 5.4 1.0
NE2 A:HIS119 4.1 5.6 1.0
ND1 A:HIS94 4.1 5.9 1.0
ND1 A:HIS96 4.1 6.5 1.0
C4 A:WWO302 4.2 6.1 1.0
CG A:HIS94 4.2 5.7 1.0
CG A:HIS96 4.2 6.1 1.0
CE1 A:HIS200 4.2 10.6 1.0
O8 A:WWO302 4.2 6.4 1.0
CD2 A:HIS119 4.2 5.5 1.0
O A:HOH599 4.3 12.0 1.0
ND1 A:HIS200 4.7 11.3 1.0
F27 A:WWO302 4.7 7.1 1.0
C5 A:WWO302 4.8 6.4 1.0
CD A:GLU106 4.8 5.3 1.0
O A:HOH577 4.9 14.2 1.0
F12 A:WWO302 4.9 7.0 1.0
C3 A:WWO302 4.9 6.4 1.0
CH2 A:TRP209 5.0 6.7 1.0

Reference:

A.Smirnov, E.Manakova, S.Grazulis, D.Matulis. Crystal Structure of Chimeric Carbonic Anhydrase I with 3-(Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide To Be Published.
Page generated: Sun Oct 27 23:32:23 2024

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