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Zinc in PDB 5nw7: Crystal Structure of Candida Albicans Phosphomannose Isomerase in Complex with Inhibitor

Enzymatic activity of Crystal Structure of Candida Albicans Phosphomannose Isomerase in Complex with Inhibitor

All present enzymatic activity of Crystal Structure of Candida Albicans Phosphomannose Isomerase in Complex with Inhibitor:
5.3.1.8;

Protein crystallography data

The structure of Crystal Structure of Candida Albicans Phosphomannose Isomerase in Complex with Inhibitor, PDB code: 5nw7 was solved by I.Li De La Sierra-Gallay, L.Ahmad, S.Plancqueel, H.Van Tilbeurgh, L.Salmon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.98 / 1.85
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 87.970, 107.860, 44.030, 90.00, 90.00, 90.00
R / Rfree (%) 17.1 / 20.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Candida Albicans Phosphomannose Isomerase in Complex with Inhibitor (pdb code 5nw7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Candida Albicans Phosphomannose Isomerase in Complex with Inhibitor, PDB code: 5nw7:

Zinc binding site 1 out of 1 in 5nw7

Go back to Zinc Binding Sites List in 5nw7
Zinc binding site 1 out of 1 in the Crystal Structure of Candida Albicans Phosphomannose Isomerase in Complex with Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Candida Albicans Phosphomannose Isomerase in Complex with Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:26.3
occ:1.00
 N A:9C2502 2.0 22.6 1.0
OE2 A:GLU138 2.0 35.8 1.0
NE2 A:HIS285 2.1 20.9 1.0
O1 A:9C2502 2.1 25.9 1.0
NE2 A:HIS113 2.2 22.9 1.0
OE1 A:GLN111 2.3 25.3 1.0
N1 A:9C2502 2.8 28.9 1.0
C1 A:9C2502 2.8 25.3 1.0
CE1 A:HIS285 3.0 23.3 1.0
CD A:GLU138 3.0 35.0 1.0
CD2 A:HIS285 3.1 21.7 1.0
CE1 A:HIS113 3.1 22.4 1.0
CD2 A:HIS113 3.1 22.7 1.0
OE1 A:GLU138 3.4 53.8 1.0
CD A:GLN111 3.4 21.4 1.0
CG A:GLN111 4.0 21.1 1.0
O A:HOH789 4.2 33.0 1.0
ND1 A:HIS285 4.2 22.7 1.0
CG A:HIS285 4.2 21.0 1.0
ND1 A:HIS113 4.3 20.0 1.0
C2 A:9C2502 4.3 24.7 1.0
CG A:HIS113 4.3 21.1 1.0
CG A:GLU138 4.4 30.7 1.0
CE A:LYS136 4.5 29.0 1.0
NZ A:LYS136 4.5 26.7 1.0
NE2 A:GLN111 4.5 21.6 1.0
C4 A:9C2502 4.7 20.7 1.0
C3 A:9C2502 4.8 25.6 1.0
O2 A:9C2502 5.0 25.8 1.0

Reference:

L.Ahmad, S.Plancqueel, V.Dubosclard, N.Lazar, W.Ghattas, I.Li De La Sierra-Gallay, H.Van Tilbeurgh, L.Salmon. Crystal Structure of Phosphomannose Isomerase From Candida Albicans Complexed with 5-Phospho-D-Arabinonhydrazide. Febs Lett. V. 592 1667 2018.
ISSN: ISSN 1873-3468
PubMed: 29687459
DOI: 10.1002/1873-3468.13059
Page generated: Sun Oct 27 23:06:27 2024

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