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Zinc in PDB 5m3h: Bat Influenza A/H17N10 Polymerase Bound to Four Heptad Repeats of Serine 5 Phosphorylated Pol II Ctd

Enzymatic activity of Bat Influenza A/H17N10 Polymerase Bound to Four Heptad Repeats of Serine 5 Phosphorylated Pol II Ctd

All present enzymatic activity of Bat Influenza A/H17N10 Polymerase Bound to Four Heptad Repeats of Serine 5 Phosphorylated Pol II Ctd:
2.7.7.48;

Protein crystallography data

The structure of Bat Influenza A/H17N10 Polymerase Bound to Four Heptad Repeats of Serine 5 Phosphorylated Pol II Ctd, PDB code: 5m3h was solved by M.Lukarska, A.Pflug, S.Cusack, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.53 / 2.50
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 269.490, 147.520, 88.480, 90.00, 97.22, 90.00
R / Rfree (%) 21 / 24.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Bat Influenza A/H17N10 Polymerase Bound to Four Heptad Repeats of Serine 5 Phosphorylated Pol II Ctd (pdb code 5m3h). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Bat Influenza A/H17N10 Polymerase Bound to Four Heptad Repeats of Serine 5 Phosphorylated Pol II Ctd, PDB code: 5m3h:

Zinc binding site 1 out of 1 in 5m3h

Go back to Zinc Binding Sites List in 5m3h
Zinc binding site 1 out of 1 in the Bat Influenza A/H17N10 Polymerase Bound to Four Heptad Repeats of Serine 5 Phosphorylated Pol II Ctd


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Bat Influenza A/H17N10 Polymerase Bound to Four Heptad Repeats of Serine 5 Phosphorylated Pol II Ctd within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn801

b:74.1
occ:1.00
 O B:HOH977 3.3 52.0 1.0
OD1 A:ASP421 3.4 44.7 1.0
OD2 A:ASP421 3.4 47.0 1.0
ND1 B:HIS562 3.7 40.9 1.0
CG A:ASP421 3.8 37.5 1.0
NZ B:LYS553 3.8 60.2 1.0
CD B:ARG556 4.2 50.0 1.0
CD B:LYS553 4.3 58.7 1.0
CE1 B:HIS562 4.4 48.2 1.0
CE2 B:TYR557 4.5 54.6 1.0
CE B:LYS553 4.5 56.0 1.0
CB B:ARG556 4.6 40.7 1.0
NH1 B:ARG556 4.8 42.5 1.0
CG B:HIS562 4.8 48.0 1.0
CD2 B:TYR557 4.9 56.1 1.0

Reference:

M.Lukarska, G.Fournier, A.Pflug, P.Resa-Infante, S.Reich, N.Naffakh, S.Cusack. Structural Basis of An Essential Interaction Between Influenza Polymerase and Pol II Ctd. Nature V. 541 117 2017.
ISSN: ESSN 1476-4687
PubMed: 28002402
DOI: 10.1038/NATURE20594
Page generated: Sun Oct 27 21:42:14 2024

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