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Zinc in PDB 5lps: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5, 6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H-Imidazo[4,5- G]Quinazolin-8(7H)-OneEnzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5, 6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H-Imidazo[4,5- G]Quinazolin-8(7H)-One
All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5, 6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H-Imidazo[4,5- G]Quinazolin-8(7H)-One:
2.4.2.29; Protein crystallography data
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5, 6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H-Imidazo[4,5- G]Quinazolin-8(7H)-One, PDB code: 5lps
was solved by
F.R.Ehrmann,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5, 6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H-Imidazo[4,5- G]Quinazolin-8(7H)-One
(pdb code 5lps). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5, 6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H-Imidazo[4,5- G]Quinazolin-8(7H)-One, PDB code: 5lps: Zinc binding site 1 out of 1 in 5lpsGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-2-(Methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5, 6-Tetramethoxytetrahydro-2H-Pyran-2-Yl)Ethyl)-1H-Imidazo[4,5- G]Quinazolin-8(7H)-One
![]() Mono view ![]() Stereo pair view
Reference:
F.R.Ehrmann,
T.Botzanowski,
T.Pfaffender,
A.Heine,
F.Diederich,
S.Sanglier-Cianferani,
G.Klebe.
Carbohydrate-Based Inhibitors Targeting the Ribose-34 Pocket of Z.Mobilis Tgt and Changing the Oligomeric State of the Homodimer To Be Published.
Page generated: Sun Oct 27 21:14:31 2024
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