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Zinc in PDB 5lpo: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-(Methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5- Trimethoxytetrahydrofuran-2-Yl)Ethyl)-1H-Imidazo[4,5-G]Quinazolin- 8(7H)-One

Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-(Methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5- Trimethoxytetrahydrofuran-2-Yl)Ethyl)-1H-Imidazo[4,5-G]Quinazolin- 8(7H)-One

All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-(Methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5- Trimethoxytetrahydrofuran-2-Yl)Ethyl)-1H-Imidazo[4,5-G]Quinazolin- 8(7H)-One:
2.4.2.29;

Protein crystallography data

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-(Methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5- Trimethoxytetrahydrofuran-2-Yl)Ethyl)-1H-Imidazo[4,5-G]Quinazolin- 8(7H)-One, PDB code: 5lpo was solved by F.R.Ehrmann, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.44 / 1.42
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 84.662, 64.819, 71.241, 90.00, 93.53, 90.00
R / Rfree (%) 13.2 / 16.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-(Methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5- Trimethoxytetrahydrofuran-2-Yl)Ethyl)-1H-Imidazo[4,5-G]Quinazolin- 8(7H)-One (pdb code 5lpo). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-(Methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5- Trimethoxytetrahydrofuran-2-Yl)Ethyl)-1H-Imidazo[4,5-G]Quinazolin- 8(7H)-One, PDB code: 5lpo:

Zinc binding site 1 out of 1 in 5lpo

Go back to Zinc Binding Sites List in 5lpo
Zinc binding site 1 out of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-(Methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5- Trimethoxytetrahydrofuran-2-Yl)Ethyl)-1H-Imidazo[4,5-G]Quinazolin- 8(7H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-(Methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5- Trimethoxytetrahydrofuran-2-Yl)Ethyl)-1H-Imidazo[4,5-G]Quinazolin- 8(7H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn406

b:15.8
occ:1.00
 ND1 A:HIS349 2.1 13.6 1.0
SG A:CYS323 2.3 16.0 1.0
SG A:CYS318 2.3 17.6 1.0
SG A:CYS320 2.3 16.3 1.0
CE1 A:HIS349 2.9 14.7 1.0
CB A:CYS323 3.3 17.3 1.0
CG A:HIS349 3.3 13.0 1.0
CB A:CYS318 3.3 18.2 1.0
CB A:CYS320 3.4 17.5 1.0
CB A:HIS349 3.7 12.9 1.0
N A:CYS323 3.9 17.3 1.0
N A:CYS320 4.1 20.5 1.0
NE2 A:HIS349 4.1 13.9 1.0
CA A:HIS349 4.2 13.0 1.0
CA A:CYS323 4.2 17.4 1.0
CA A:CYS320 4.2 19.4 1.0
CD2 A:HIS349 4.3 12.9 1.0
O A:HIS349 4.5 13.6 1.0
CA A:CYS318 4.6 20.4 1.0
C A:CYS318 4.7 22.3 1.0
C A:CYS320 4.7 20.3 1.0
O A:CYS320 4.7 19.6 1.0
C A:HIS349 4.8 12.5 1.0
O A:CYS318 4.8 22.0 1.0
CB A:VAL322 4.8 16.8 1.0
C A:VAL322 5.0 16.9 1.0

Reference:

F.R.Ehrmann, T.Botzanowski, T.Pfaffender, A.Heine, F.Diederich, S.Sanglier-Cianferani, G.Klebe. Carbohydrate-Based Inhibitors Targeting the Ribose-34 Pocket of Z.Mobilis Tgt and Changing the Oligomeric State of the Homodimer To Be Published.
Page generated: Sun Oct 27 21:13:27 2024

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