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Atomistry » Zinc » PDB 5k1b-5kay » 5k32 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 5k1b-5kay » 5k32 » |
Zinc in PDB 5k32: PDE4D Crystal Structure in Complex with Small Molecule InhibitorEnzymatic activity of PDE4D Crystal Structure in Complex with Small Molecule Inhibitor
All present enzymatic activity of PDE4D Crystal Structure in Complex with Small Molecule Inhibitor:
3.1.4.53; Protein crystallography data
The structure of PDE4D Crystal Structure in Complex with Small Molecule Inhibitor, PDB code: 5k32
was solved by
V.Segarra,
B.Hernandez,
R.Roberts,
J.Gracia,
M.Soler,
I.Bonin,
J.Aymami,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5k32:
The structure of PDE4D Crystal Structure in Complex with Small Molecule Inhibitor also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the PDE4D Crystal Structure in Complex with Small Molecule Inhibitor
(pdb code 5k32). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the PDE4D Crystal Structure in Complex with Small Molecule Inhibitor, PDB code: 5k32: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 5k32Go back to![]() ![]()
Zinc binding site 1 out
of 2 in the PDE4D Crystal Structure in Complex with Small Molecule Inhibitor
![]() Mono view ![]() Stereo pair view
Zinc binding site 2 out of 2 in 5k32Go back to![]() ![]()
Zinc binding site 2 out
of 2 in the PDE4D Crystal Structure in Complex with Small Molecule Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
R.S.Roberts,
S.Sevilla,
M.Ferrer,
J.Taltavull,
B.Hernandez,
V.Segarra,
J.Gracia,
M.D.Lehner,
A.Gavalda,
M.Andres,
J.Cabedo,
D.Vilella,
P.Eichhorn,
E.Calama,
C.Carcasona,
M.Miralpeix.
4-Amino-7,8-Dihydro-1,6-Naphthyridin-5(6 H)-Ones As Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships. J. Med. Chem. V. 61 2472 2018.
Page generated: Sun Oct 27 19:59:18 2024
ISSN: ISSN 1520-4804 PubMed: 29502405 DOI: 10.1021/ACS.JMEDCHEM.7B01751 |
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