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Zinc in PDB 5jgo: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with Allyl (2-(Methylamino)-8-Oxo-7,8-Dihydro-1H-Imidazo[4,5-G]Quinazolin- 6-Yl)Carbamate

Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with Allyl (2-(Methylamino)-8-Oxo-7,8-Dihydro-1H-Imidazo[4,5-G]Quinazolin- 6-Yl)Carbamate

All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with Allyl (2-(Methylamino)-8-Oxo-7,8-Dihydro-1H-Imidazo[4,5-G]Quinazolin- 6-Yl)Carbamate:
2.4.2.29;

Protein crystallography data

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with Allyl (2-(Methylamino)-8-Oxo-7,8-Dihydro-1H-Imidazo[4,5-G]Quinazolin- 6-Yl)Carbamate, PDB code: 5jgo was solved by F.R.Ehrmann, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.62 / 1.37
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.888, 65.134, 70.835, 90.00, 96.13, 90.00
R / Rfree (%) 13.5 / 16.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with Allyl (2-(Methylamino)-8-Oxo-7,8-Dihydro-1H-Imidazo[4,5-G]Quinazolin- 6-Yl)Carbamate (pdb code 5jgo). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with Allyl (2-(Methylamino)-8-Oxo-7,8-Dihydro-1H-Imidazo[4,5-G]Quinazolin- 6-Yl)Carbamate, PDB code: 5jgo:

Zinc binding site 1 out of 1 in 5jgo

Go back to Zinc Binding Sites List in 5jgo
Zinc binding site 1 out of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with Allyl (2-(Methylamino)-8-Oxo-7,8-Dihydro-1H-Imidazo[4,5-G]Quinazolin- 6-Yl)Carbamate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with Allyl (2-(Methylamino)-8-Oxo-7,8-Dihydro-1H-Imidazo[4,5-G]Quinazolin- 6-Yl)Carbamate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn404

b:13.3
occ:1.00
 ND1 A:HIS349 2.1 12.2 1.0
SG A:CYS323 2.3 13.6 1.0
SG A:CYS318 2.3 15.2 1.0
SG A:CYS320 2.3 13.4 1.0
CE1 A:HIS349 2.9 13.6 1.0
CB A:CYS318 3.2 16.0 1.0
CG A:HIS349 3.3 12.3 1.0
CB A:CYS323 3.3 12.4 1.0
CB A:CYS320 3.4 12.8 1.0
CB A:HIS349 3.7 11.2 1.0
N A:CYS323 3.9 13.4 1.0
NE2 A:HIS349 4.1 13.6 1.0
CA A:HIS349 4.1 11.1 1.0
N A:CYS320 4.1 15.2 1.0
CA A:CYS323 4.2 13.0 1.0
CA A:CYS320 4.3 14.3 1.0
CD2 A:HIS349 4.3 13.6 1.0
O A:HIS349 4.5 11.8 1.0
CA A:CYS318 4.6 16.0 1.0
C A:CYS318 4.7 17.1 1.0
O A:CYS320 4.7 14.0 1.0
C A:CYS320 4.7 13.3 1.0
C A:HIS349 4.8 10.5 1.0
CB A:VAL322 4.8 11.2 1.0
O A:CYS318 4.8 17.9 1.0
C A:VAL322 4.9 13.0 1.0

Reference:

F.R.Ehrmann, C.Hohn, A.Heine, K.Reuter, F.Diederich, G.Klebe. Carbamate-Protected Lin-Benzoguanines As Promising Candidates For Improving Solubility and Membrane Permeability To Be Published.
Page generated: Sun Oct 27 18:56:15 2024

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