Atomistry » Zinc » PDB 5hp2-5i3l » 5i03
Atomistry »
  Zinc »
    PDB 5hp2-5i3l »
      5i03 »

Zinc in PDB 5i03: Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One

Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One

All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 5i03 was solved by F.R.Ehrmann, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.49 / 1.73
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 85.140, 64.641, 71.017, 90.00, 93.60, 90.00
R / Rfree (%) 18.1 / 20.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One (pdb code 5i03). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 5i03:

Zinc binding site 1 out of 1 in 5i03

Go back to Zinc Binding Sites List in 5i03
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn403

b:21.8
occ:1.00
 ND1 A:HIS349 2.2 17.2 1.0
SG A:CYS320 2.3 24.5 1.0
SG A:CYS323 2.3 24.6 1.0
SG A:CYS318 2.3 27.3 1.0
CE1 A:HIS349 3.0 16.6 1.0
CB A:CYS318 3.3 26.4 1.0
CG A:HIS349 3.3 18.2 1.0
CB A:CYS323 3.3 24.8 1.0
CB A:CYS320 3.3 24.2 1.0
CB A:HIS349 3.8 20.1 1.0
N A:CYS323 3.9 26.2 1.0
N A:CYS320 4.1 23.4 1.0
NE2 A:HIS349 4.2 15.2 1.0
CA A:HIS349 4.2 20.8 1.0
CA A:CYS320 4.2 24.4 1.0
CA A:CYS323 4.3 25.2 1.0
CD2 A:HIS349 4.4 16.3 1.0
O A:HIS349 4.5 20.6 1.0
CA A:CYS318 4.6 26.3 1.0
C A:CYS318 4.7 27.1 1.0
O A:CYS320 4.7 23.2 1.0
C A:CYS320 4.7 24.3 1.0
C A:HIS349 4.8 20.0 1.0
CB A:VAL322 4.8 26.1 1.0
O A:CYS318 4.8 27.1 1.0
CB A:LEU314 5.0 19.8 1.0
C A:VAL322 5.0 25.7 1.0

Reference:

F.R.Ehrmann, J.Stojko, A.Heine, F.Diederich, K.Reuter, S.Sanglier-Cianferani, G.Klebe. Co-Crystallization, Isothermal Titration Calorimetry and Nanoesi-Ms Reveal Dimer Disturbing Inhibitors To Be Published.
Page generated: Sun Oct 27 17:44:01 2024

Last articles

Mn in 8JKK
Mn in 8JNK
Mn in 8JNR
Mn in 8IRI
Mn in 8JGP
Mn in 8JBM
Mn in 8JDZ
Mn in 8JDY
Mn in 8JDX
Mn in 8JDV
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy