Zinc in PDB 5h65: Crystal Structure of Human POT1 and TPP1

The structure of Crystal Structure of Human POT1 and TPP1, PDB code: 5h65 was solved by C.Chen, J.Wu, M.Lei, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.91 / 2.10
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	49.231, 87.824, 87.120, 90.00, 90.00, 90.00
R / Rfree (%)	19.6 / 24.8

The binding sites of Zinc atom in the Crystal Structure of Human POT1 and TPP1 (pdb code 5h65). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human POT1 and TPP1, PDB code: 5h65:

Zinc binding site 1 out of 1 in the Crystal Structure of Human POT1 and TPP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human POT1 and TPP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn701 b:31.7 occ:1.00 SG A:CYS503 2.3 29.2 1.0 SG A:CYS382 2.3 28.5 1.0 SG A:CYS506 2.3 33.4 1.0 SG A:CYS385 2.3 35.1 1.0 CB A:CYS382 3.1 27.1 1.0 CB A:CYS503 3.3 31.6 1.0 CB A:CYS385 3.3 33.4 1.0 CB A:CYS506 3.3 31.0 1.0 N A:CYS385 3.7 36.5 1.0 N A:CYS506 4.0 34.2 1.0 CA A:CYS385 4.1 33.7 1.0 CA A:CYS506 4.3 28.9 1.0 CB A:LYS384 4.4 44.0 1.0 CB A:GLN505 4.4 43.8 1.0 CA A:CYS382 4.6 30.2 1.0 CA A:CYS503 4.7 24.1 1.0 C A:LYS384 4.8 41.6 1.0 OE1 A:GLN505 4.8 62.1 1.0 C A:CYS385 4.8 39.5 1.0 CD A:GLN505 4.9 69.1 1.0 C A:GLN505 4.9 35.4 1.0

C.Chen, P.Gu, J.Wu, X.Chen, S.Niu, H.Sun, L.Wu, N.Li, J.Peng, S.Shi, C.Fan, M.Huang, C.C.Wong, Q.Gong, C.Kumar-Sinha, R.Zhang, L.Pusztai, R.Rai, S.Chang, M.Lei. Structural Insights Into POT1-TPP1 Interaction and POT1 C-Terminal Mutations in Human Cancer. Nat Commun V. 8 14929 2017.
ISSN: ESSN 2041-1723
PubMed: 28393832
DOI: 10.1038/NCOMMS14929