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Zinc in PDB 5cpr: The Novel SUV4-20 Inhibitor A-196 Verifies A Role For Epigenetics in Genomic Integrity

Enzymatic activity of The Novel SUV4-20 Inhibitor A-196 Verifies A Role For Epigenetics in Genomic Integrity

All present enzymatic activity of The Novel SUV4-20 Inhibitor A-196 Verifies A Role For Epigenetics in Genomic Integrity:
2.1.1.43;

Protein crystallography data

The structure of The Novel SUV4-20 Inhibitor A-196 Verifies A Role For Epigenetics in Genomic Integrity, PDB code: 5cpr was solved by C.G.Jakob, A.K.Upadhyay, C.Sun, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.47 / 2.22
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 42.209, 47.913, 129.072, 90.00, 90.00, 90.00
R / Rfree (%) 19 / 24.9

Other elements in 5cpr:

The structure of The Novel SUV4-20 Inhibitor A-196 Verifies A Role For Epigenetics in Genomic Integrity also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the The Novel SUV4-20 Inhibitor A-196 Verifies A Role For Epigenetics in Genomic Integrity (pdb code 5cpr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the The Novel SUV4-20 Inhibitor A-196 Verifies A Role For Epigenetics in Genomic Integrity, PDB code: 5cpr:

Zinc binding site 1 out of 1 in 5cpr

Go back to Zinc Binding Sites List in 5cpr
Zinc binding site 1 out of 1 in the The Novel SUV4-20 Inhibitor A-196 Verifies A Role For Epigenetics in Genomic Integrity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Novel SUV4-20 Inhibitor A-196 Verifies A Role For Epigenetics in Genomic Integrity within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn401

b:22.6
occ:1.00
 SG B:CYS324 2.2 24.6 1.0
SG B:CYS321 2.2 19.4 1.0
SG B:CYS319 2.3 23.3 1.0
SG B:CYS275 2.4 21.6 1.0
CB B:CYS319 3.2 19.3 1.0
CB B:CYS324 3.3 20.4 1.0
CB B:CYS275 3.4 17.4 1.0
CB B:CYS321 3.5 15.7 1.0
N B:CYS321 4.0 15.3 1.0
N B:CYS275 4.0 17.5 1.0
N B:CYS324 4.1 20.8 1.0
CA B:CYS324 4.2 20.5 1.0
CA B:CYS321 4.2 15.6 1.0
CA B:CYS275 4.3 17.7 1.0
NE2 B:HIS273 4.3 19.3 1.0
O B:HOH635 4.4 34.2 1.0
CD2 B:HIS273 4.4 19.0 1.0
CA B:CYS319 4.5 19.2 1.0
C B:CYS319 4.6 22.8 1.0
C B:CYS321 4.9 23.2 1.0
O B:CYS319 4.9 22.4 1.0
O B:CYS321 4.9 22.3 1.0
N B:GLU320 5.0 18.4 1.0

Reference:

K.D.Bromberg, T.R.Mitchell, A.K.Upadhyay, C.G.Jakob, M.A.Jhala, K.M.Comess, L.M.Lasko, C.Li, C.T.Tuzon, Y.Dai, F.Li, M.S.Eram, A.Nuber, N.B.Soni, V.Manaves, M.A.Algire, R.F.Sweis, M.Torrent, G.Schotta, C.Sun, M.R.Michaelides, A.R.Shoemaker, C.H.Arrowsmith, P.J.Brown, V.Santhakumar, A.Martin, J.C.Rice, G.G.Chiang, M.Vedadi, D.Barsyte-Lovejoy, W.N.Pappano. The SUV4-20 Inhibitor A-196 Verifies A Role For Epigenetics in Genomic Integrity. Nat. Chem. Biol. V. 13 317 2017.
ISSN: ESSN 1552-4469
PubMed: 28114273
DOI: 10.1038/NCHEMBIO.2282
Page generated: Sun Oct 27 14:26:07 2024

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